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Your search keyword '"chronobiological rhythm"' showing total 2 results
Start Over Descriptor "chronobiological rhythm" Topic bone remodeling
2 results on '"chronobiological rhythm"'

1. Cyclical behavior of bone remodeling and bone loss in healthy women after menopause: results of a prospective study

Author

Mazzuoli, G., Marinucci, D., D’erasmo, E., Acca, M., Pisani, D., Rinaldi, M.G., Bianchi, G., Diacinti, D., and Minisola, S.

Subjects
*LUMBOSACRAL region, *BONES, *DISEASES in women
Abstract

Annual changes in lumbar bone mineral density (LBMD) and bone remodeling markers were measured in 238 healthy pre- and postmenopausal women, aged 45–74 years. The subjects were divided into groups according to their menstrual status and years since menopause. The results obtained indicate that bone loss is not a constant process over time but rather exhibits cyclical damping oscillations. When the log-linear trend of LBMD decrement was transformed into a constant by considering annual percentage changes, the presence of a cyclical component of 7 years was evident. By employing a harmonic regression model, the cyclical component was also statistically significant on baseline data. The cyclical behavior of LBMD decrement corresponded to an analogous behavior of the bone remodeling markers. These results suggest that a lack of estrogen acts as a synchronizer on bone remodeling by triggering a latent cyclical rhythm of bone loss that persists throughout life after menopause. The existence of a chronobiological rhythm of bone loss starting after menopause, if confirmed, could have important clinical implications. [Copyright &y& Elsevier]

Published
2002
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2. Cyclical behavior of bone remodeling and bone loss in healthy women after menopause: results of a prospective study

Author

D. Pisani, M.G Rinaldi, Salvatore Minisola, D. Diacinti, Gianfranco Mazzuoli, D Marinucci, D'Erasmo E, Gerolamo Bianchi, and M. Acca

Subjects
medicine.medical_specialty, Periodicity, Histology, Physiology, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Bone remodeling, Rhythm, Bone Density, bone remodeling, chronobiological rhythm, lack of estrogen, menopausal bone loss, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Osteoporosis, Postmenopausal, Aged, Bone mineral, Chronobiology, Analysis of Variance, Lumbar Vertebrae, business.industry, Middle Aged, medicine.disease, Osteopenia, Menopause, Endocrinology, Estrogen, Female, Bone Remodeling, business, Follow-Up Studies
Abstract

Annual changes in lumbar bone mineral density (LBMD) and bone remodeling markers were measured in 238 healthy pre- and postmenopausal women, aged 45-74 years. The subjects were divided into groups according to their menstrual status and years since menopause. The results obtained indicate that bone loss is not a constant process over time but rather exhibits cyclical damping oscillations. When the log-linear trend of LBMD decrement was transformed into a constant by considering annual percentage changes, the presence of a cyclical component of 7 years was evident. By employing a harmonic regression model, the cyclical component was also statistically significant on baseline data. The cyclical behavior of LBMD decrement corresponded to an analogous behavior of the bone remodeling markers. These results suggest that a lack of estrogen acts as a synchronizer on bone remodeling by triggering a latent cyclical rhythm of bone loss that persists throughout life after menopause. The existence of a chronobiological rhythm of bone loss starting after menopause, if confirmed, could have important clinical implications.

Published
2003

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