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Start Over Author "Scarcia G." Topic bone marrow
2 results on '"Scarcia G."'

1. Increased CD34+ cell peripheral traffic appears to be an unique feature of the allergic inflammation.

Author

Mastrandrea F, Coradduzza G, Resta F, Cadario G, Rollo MA, Marengo F, Mazza P, Pajno G, Di Pasquale G, Minardi A, Scarcia G, and Serio G

Subjects
Adult, Antigens, CD34 analysis, Cell Lineage, Cell Movement, Female, Fever physiopathology, Flow Cytometry, Humans, Infections complications, Inflammation etiology, Male, Middle Aged, Stress, Physiological physiopathology, Bone Marrow physiopathology, Hematopoietic Stem Cells physiology, Hypersensitivity complications, Inflammation physiopathology
Abstract

Evidence has been cumulated during the last years concerning the immaturity of the cells involved in the local and systemic aspects of allergic inflammation. Hematopoietic precursors (HPC) are mobilized from the bone matrix as multipotent cells or, more often, as progenitors that, after the initial white-lineage commitment reach through the peripheral blood (PB) their final destinations constituted by the target organs of allergy. Although several studies have investigated the CD34+ cells traffic and location at the level of the inflamed peripheral mucosae in allergic populations, limited information is available on their behaviour on the time-course of infectious diseases. The current study thus was designed to asses the peripheral traffic of CD34+ HPC during the infectious inflammation. To this end CD34+ HPCs have been enumerated, by flow-cytometric techniques, in PB of 24 adult healthy beings (Group A), 24 adult subjects with symptomatic extrinsic allergy (Group B) and in PB of 24 adult patients hospitalised for febrile infectious pathology (Group C). CD34+ cell values ranged 0.01-0.08% with a median of 0.03 in Group A. In Group B values ranged 0.17-0.75% with a median of 0.28 and in Group C values ranged 0.00-0.12% with a median of 0.07. Variance analysis test among the three groups was statistically significant (p<0.001) supporting the conclusion that CD34+ HPC mobilizing and increased peripheral traffic is an unique feature of the allergic inflammation.

Published
2005

2. Increased CD34+ cell peripheral traffic appears to be an unique feature of the allergic inflammation

Author

Mastrandrea, F., Coradduzza, G., Resta, F., Cadario, G., Rollo, M. -A, Marengo, F., Mazza, P., Pajno, G., Di Pasquale, G., Minardi, A., Scarcia, G., and Gabriella Serio

Subjects
Adult, Male, Fever, Allergy, Antigens, CD34, Mobilization, Infections, CD34+ cell, Bone Marrow, Cell Movement, Stress, Physiological, Allergic inflammation, Hypersensitivity, Humans, Cell Lineage, Hematopoietic precursor cell, Infectious diseases, Infectious inflammation, Peripheral traffic, Progenitor cell, Stem cell, Inflammation, Middle Aged, Flow Cytometry, Hematopoietic Stem Cells, Female
Abstract

Evidence has been cumulated during the last years concerning the immaturity of the cells involved in the local and systemic aspects of allergic inflammation. Hematopoietic precursors (HPC) are mobilized from the bone matrix as multipotent cells or, more often, as progenitors that, after the initial white-lineage commitment reach through the peripheral blood (PB) their final destinations constituted by the target organs of allergy. Although several studies have investigated the CD34+ cells traffic and location at the level of the inflamed peripheral mucosae in allergic populations, limited information is available on their behaviour on the time-course of infectious diseases. The current study thus was designed to asses the peripheral traffic of CD34+ HPC during the infectious inflammation. To this end CD34+ HPCs have been enumerated, by flow-cytometric techniques, in PB of 24 adult healthy beings (Group A), 24 adult subjects with symptomatic extrinsic allergy (Group B) and in PB of 24 adult patients hospitalised for febrile infectious pathology (Group C). CD34+ cell values ranged 0.01-0.08% with a median of 0.03 in Group A. In Group B values ranged 0.17-0.75% with a median of 0.28 and in Group C values ranged 0.00-0.12% with a median of 0.07. Variance analysis test among the three groups was statistically significant (p0.001) supporting the conclusion that CD34+ HPC mobilizing and increased peripheral traffic is an unique feature of the allergic inflammation.

Published
2005

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