1. Short-term evaluation of autologous transplantation of bone marrow-derived mesenchymal stem cells in patients with cirrhosis: Egyptian study.
- Author
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Amin MA, Sabry D, Rashed LA, Aref WM, el-Ghobary MA, Farhan MS, Fouad HA, and Youssef YA
- Subjects
- Adult, Alanine Transaminase metabolism, Aspartate Aminotransferases metabolism, Feasibility Studies, Female, Follow-Up Studies, Humans, Liver Cirrhosis metabolism, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Transplantation, Autologous, Bone Marrow surgery, Liver Cirrhosis therapy, Mesenchymal Stem Cell Transplantation, Stromal Cells transplantation
- Abstract
Background: Stem cell-based therapy has received attention as a possible alternative to organ transplantation. The aim of this study was to assess the safety and efficacy of autologous transplantation of bone marrow (BM)-derived stromal cells in post-HCV liver cirrhosis patients., Methodology: 10 × 10(6) of isolated human bone marrow (HBM)-stromal cells in 10 mL normal saline were injected in the spleen of 20 patients with end-stage liver cirrhosis guided by the ultrasonography, and then patients were followed up on monthly basis for six months., Results: A statistically significant decrease was detected in the total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) (p-value<0.01), prothrombin time (PT), and international normalized ratio (INR) levels (p-value<0.05), while a statistically significant increase in the albumin and PC (p-value<0.05) after follow-up., Conclusion: This study suggested the safety, feasibility, and efficacy of the intrasplenic injection of autologous BM stromal cells in improving liver function in Egyptian patients with cirrhosis., (© 2013 John Wiley & Sons A/S.)
- Published
- 2013
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