1. The relation between bone loss and calcium balance in women.
- Author
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Horsman A, Marshall DH, Nordin BE, Crilly RG, and Simpson M
- Subjects
- Aged, Alkaline Phosphatase blood, Bone Regeneration, Bone Resorption, Female, Femur injuries, Fractures, Bone metabolism, Humans, Hydroxyproline urine, Hyperparathyroidism metabolism, Menopause, Middle Aged, Bone and Bones metabolism, Calcium metabolism, Osteoporosis metabolism
- Abstract
1. We have examined the relation between the rate of cortical bone loss and other measured variables in 108 women, untreated and on various therapies, observed for nearly 300 patient years. The majority of the subjects were postmenopausal women with various degrees of simple osteoporosis, but a few cases of hyperparathyroidism and other calcium disorders were included. 2. Calcium balance, bone resorption rats, urinary hydroxyproline and plasma alkaline phosphatase were shown to be related to the rate of bone loss; patients with the more negative balance or the higher values of the other variables had significantly higher rates of loss. The rate of bone loss was independent of the rate of bone formation.
- Published
- 1980
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