1. The Effect of Fat-Enriched Diet on the Incidence of Spontaneous Mammary Tumors in Obese Mice
- Author
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George Brecher, Stuart L. Beal, and Samuel H. Waxler
- Subjects
Mice, Inbred C3H ,medicine.medical_specialty ,Tumor incidence ,Calorie ,Incidence (epidemiology) ,Body Weight ,Statistics as Topic ,Biology ,medicine.disease ,Dietary Fats ,Obesity ,General Biochemistry, Genetics and Molecular Biology ,Mice ,Mammary Glands, Animal ,Endocrinology ,Neoplasms ,Internal medicine ,medicine ,Animals ,Neoplasm ,Female ,Statistical analysis ,Regular diet ,Obese Mice - Abstract
SummaryC3H/HeJ mice show a high incidence of spontaneously occurring mammary tumors. Mice made experimentally obese were observed to have an earlier appearance and a greater incidence of tumors than were the normal-weight mice. A fatenriched diet increased the observed tumor incidence in normal-weight mice to about that of obese mice given a regular diet, while a fat-enriched diet further enhanced the already augmented observed yield of mammary tumors in the obese mice given a regular diet. Statistical analysis supported the dependence of tumor incidence and appearance time on the type of diet. The calories consumed by normal mice on a fat-enriched diet was considerably below that of obese mice on a regular diet, yet produced about the same tumor incidence. A specific effect of the fat-enriched diet is suggested.High caloric diets, particularly those modified to include a high portion of fat, have been reported to promote or enhance the occurrence of several types of tumors in various species of animals (...
- Published
- 1979