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Objective To explore influence of sequential feeding two kinds of high-fat diets on the body weight and blood lipids of rats．Methods 30 SD rats （male） were randomly divided into two groups: control group and study group （n＝15 in each group） . Rats in the study group were given sequential feeding two kinds of high-fat diets （high-fat diet A for 1-7 week and high-fat diet B for 8-16 week） on the basis of intraperitoneal injection of VD3 （750 000 U/kg） . Rats in the control group were only given the the basal diet. The body weight of rats were recorded once every week and the blood lipids （TC，TG，LDL-C and HDL-C） were tested every two weeks． Results The body weights of rats in the control group increased continuously during this study. The body weights of rats in the study group increased in the first 2 weeks，decreased continuously from the 3rd week to the 7th week， then increased continuously from the the 8th week after changing high-fat diet A with B. There were statistically significant differences in the body weights between the two groups at different time points except before study and the 16th week after study （ ＜0.05） . The blood lipids levels of rats in the control group were stable during the study. In the control group， the srum levels of TC， HDL-C and LDL-C of rats increased firstly and then decreased， and reached the peak values on the 6th and 4th week， respectively; the srum levels of TG had no significant change in the first 6 weeks， and gradually increased from the 8th week after changing high-fat diet A with B， and were significantly higher than those in the control group （ ＜0.05） ．Conclusion Sequential feeding two kinds of high-fat diets may accelerate the establishment of rat model of atherosclerosis [ABSTRACT FROM AUTHOR]