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Objectives: This study compared the metabolic and vascular responses, to whole-body and finger cold exposure, of a traditional population lifelong exposed to extreme cold winters with Western Europeans., Methods: Thirteen cold acclimatized Tuvan pastoralist adults (45 ± 9 years; 24.1 ± 3.2 kg/m 2 ) and 13 matched Western European controls (43 ± 15 years; 22.6 ± 1.4 kg/m 2 ) completed a whole-body cold (10°C) air exposure test and a cold-induced vasodilation (CIVD) test, which involved the immersion of the middle finger into ice-water for 30 min., Results: During the whole-body cold exposure, the durations until the onset of shivering for three monitored skeletal muscles were similar for both groups. Cold exposure increased the Tuvans' energy expenditure by (mean ± SD) 0.9 ± 0.7 kJ min -1 and the Europeans' by 1.3 ± 1.54 kJ min -1 ; these changes were not significantly different. The forearm-fingertip skin temperature gradient of the Tuvans was lower, indicating less vasoconstriction, than the Europeans during the cold exposure (0 ± 4.5°C vs. 8.8 ± 2.7°C). A CIVD response occurred in 92% of the Tuvans and 36% of the Europeans. In line, finger temperature during the CIVD test was higher in the Tuvans than the Europeans (13.4 ± 3.4°C vs. 3.9 ± 2.3°C)., Conclusion: Cold-induced thermogenesis and the onset of shivering were similar in both populations. However, vasoconstriction at the extremities was reduced in the Tuvans compared to the Europeans. The enhanced blood flow to the extremities could be beneficial for living in an extreme cold environment by improving dexterity, comfort, and reducing the risk of cold-injuries., (© 2023 The Authors. American Journal of Human Biology published by Wiley Periodicals LLC.)

Humans spend approximately 80-90% of their time indoors. In current practice, indoor temperatures in many buildings are controlled very tightly. However, allowing more variation in indoor temperature results in more energy-efficient buildings and could potentially improve human metabolic and cardiovascular health. Therefore, this study aimed to evaluate the effect of a drifting ambient temperature versus a fixed ambient temperature on thermal physiological parameters and subjective perception. A cross-over intervention design was conducted in 16 healthy men (age 26 ± 4 y; BMI 23.0 ± 1.7 kg/m 2 ) between July 2018 and May 2019. All participants underwent two whole-day (8:30-17:00) experimental sessions, during which they were exposed to a drifting (17-25°C with a morning ramp of 2.58°C/h and afternoon ramp of -2.58°C/h) or constant ambient temperature (21°C) in randomized order. The experiments took place in respiratory chambers, which simulated a typical office environment and in which temperature conditions can be controlled accurately. Throughout the experimental sessions core and skin temperature, heart rate, blood pressure, energy expenditure as well as activity levels were measured. Subjective thermal perception, such as thermal comfort and sensation, was assessed by questionnaires every 30 min. Results reveal that energy expenditure was higher in the morning during the drifting session, which was accompanied by an increase in activity levels. Both drifting and fixed sessions were judged as comfortable although during the drift thermal comfort was lower in the morning and afternoon and higher during midday. The results indicate that a drifting ambient temperature can be applied in practice, and as such, can contribute to a healthier and more sustainable built environment. More research is needed to understand the role of a drifting temperature on the long term., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)

To date, the position and shape of the human thermoneutral zone (TNZ) remain uncertain. Indications exist that the individual TNZ might be influenced by age, body composition and level of acclimatisation. The objective of the present study was to explore the individual metabolic TNZ, using dynamic thermal conditions to assess both metabolic lower and upper critical temperatures (LCT and UCT) and, secondly, to test the effect of passive mild heat acclimation on the human metabolic TNZ. A dynamic protocol consisting of two experimental conditions was designed: starting from a thermoneutral condition (28.8 ± 0.3 °C), temperature gradually increased to 37.5 ± 0.6 °C during warming (UP) or decreased to 17.8 ± 0.6 °C during cooling (DOWN). For six participants, temperature increased further to 41.6 ± 1.0 °C during UP. Eleven healthy men (19-31 y) underwent UP and DOWN twice, i.e. before and after passive mild heat acclimation (PMHA, 7 days at ~33 °C for 6 h/day). Energy expenditure, body temperatures and heart rate were measured during UP and DOWN. We show that the generally assumed LCT of approximately 28 °C for an average male person does not match the dynamically assessed LCTs in this study, as those were considerably lower in most cases (23.3 ± 3.2 °C pre-acclimation; 23.4 ± 2.0 °C post-acclimation). Distinct inter-individual variation of the dynamic LCT was evident (range pre-PMHA:9.7 °C; post-PMHA:5.4 °C). Regarding the metabolic response to increasing temperatures, only minor or no increases in energy metabolism occurred. PMHA did not significantly change the positioning of the LCTs, but lowered Tcore (pre-PMHA: -0.13 ± 0.13 °C, P = 0.011; post-PMHA: -0.14 ± 0.15 °C, P = 0.026) and affected skin temperature distribution. The applied method allowed for the determination of individual dynamic LCTs, however, distinct metabolic UCTs were not evident in humans. For a better understanding of the human UCT, future studies should incorporate individualised temperature ranges and also a measurement of evaporative heat loss, to allow for a two-factor analysis of both metabolic and evaporative human UCT., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Light is essential for vision and plays an important role in non-visual responses, thus affecting alertness, mood and circadian rhythms. Furthermore, light influences physiological processes, such as thermoregulation, and therefore may be expected to play a role in thermal comfort (TC) as well. A systematic literature search was performed for human studies exploring the relation between ocular light exposure, thermophysiology and TC. Experimental results show that light in the evening can reduce melatonin secretion, delay the natural decline in core body temperature (CBT) and slow down the increase in distal skin temperature. In the morning though, bright light can result in a faster decline in melatonin levels, thus enabling a faster increase in CBT. Moreover, the colour of light can affect temperature perception of the environment. Light with colour tones towards the red end of the visual spectrum leads to a warmer perception compared to more bluish light tones. It should be noted, however, that many results of light on thermal responses are inconclusive, and a theoretical framework is largely lacking. In conclusion, light is capable of evoking thermophysiological responses and visual input can alter perception of the thermal environment. Therefore, lighting conditions should be taken into consideration during thermophysiological research and in the design of indoor climates., (© 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.)

Skin blood flow (SBF) is a key player in human thermoregulation during mild thermal challenges. Various numerical models of SBF regulation exist. However, none explicitly incorporates the neurophysiology of thermal reception. This study tested a new SBF model that is in line with experimental data on thermal reception and the neurophysiological pathways involved in thermoregulatory SBF control. Additionally, a numerical thermoregulation model was used as a platform to test the function of the neurophysiological SBF model for skin temperature simulation. The prediction-error of the SBF-model was quantified by root-mean-squared-residual (RMSR) between simulations and experimental measurement data. Measurement data consisted of SBF (abdomen, forearm, hand), core and skin temperature recordings of young males during three transient thermal challenges (1 development and 2 validation). Additionally, ThermoSEM, a thermoregulation model, was used to simulate body temperatures using the new neurophysiological SBF-model. The RMSR between simulated and measured mean skin temperature was used to validate the model. The neurophysiological model predicted SBF with an accuracy of RMSR < 0.27. Tskin simulation results were within 0.37 °C of the measured mean skin temperature. This study shows that (1) thermal reception and neurophysiological pathways involved in thermoregulatory SBF control can be captured in a mathematical model, and (2) human thermoregulation models can be equipped with SBF control functions that are based on neurophysiology without loss of performance. The neurophysiological approach in modelling thermoregulation is favourable over engineering approaches because it is more in line with the underlying physiology.

The question we address here is whether a mild increase in environmental temperature affects body temperature and energy expenditure, focusing on the individual variation in the relation between energy expenditure and body temperature. We studied eight normal weight healthy females, 48 h at an ambient temperature of 22 degrees C, and 48 h at 27 degrees C. Energy expenditure (EE) was measured in a respiration chamber. Subjects' skin temperature was measured continuously from 8:00 a.m. until 12:00 p.m.: forehead, infraclavicular zone, thigh, hand, and foot. Core temperature was determined tympanically. Body composition was determined by under water weighing. Exposure to 27 degrees C caused a significant increase in body temperature (both skin and core), a decrease in temperature gradients, and a decrease in energy expenditure. At 27 degrees C 24 h EE, adjusted for body composition, was significantly related to body tympanic temperature. The decrease in 24 h EE, at 27 degrees C ambient temperature, was significantly, negatively related to the increase in T(tym), indicating individual responses in adaptation to elevated ambient temperature. Changes in temperature gradient (comparing 27 degrees C with 22 degrees C) were negatively related to changes in EE. This shows that individuals differ in their response to an increase in environmental temperature regarding the relative contribution of insulative or metabolic adjustments.

A biological perspective is used to understand thermal sensation. The main premise is that thermal sensation serves an organism for the regulation of body temperature. A biological concept related to this premise is the physiological thermoneutral zone (TNZ). Within the TNZ the body can adjust body tissue insulation to maintain thermal balance and a stable core temperature. The approach presented here is based on the assumption that humans express neutral thermal sensation near the centre of their TNZ. To test this hypothesis, dTNZopis defined as the distance between measured operative temperature and the centre of the TNZ, and dTNZskas the distance between measured mean skin temperature and the centre of the TNZ. The TNZ centre is calculated with a biophysical model using measured data from a climate chamber study with 16 female subjects. Regression between observed thermal sensation votes (TSV) and dTNZxrevealed that the intercept corresponds with a slightly higher-than-neutral TSV and a strong linear relationship between TSV and dTNZopand dTNZsk. This approach shows great potential to improve the understanding of human thermal sensation in the context of physiology. [ABSTRACT FROM PUBLISHER]

Passive mild heat acclimation (PMHA) reflects realistic temperature challenges encountered in everyday life. Active heat acclimation, combining heat exposure and exercise, influences several important thermophysiological parameters; for example, it decreases core temperature and enhances heat exchange via the skin. However, it is unclear whether PMHA elicits comparable adaptations. Therefore, this study investigated the effect of PMHA on thermophysiological parameters. Participants were exposed to slightly increased temperatures (∼33°C/22% RH) for 6 h/d over 7 consecutive days. To study physiologic responses before and after PMHA, participants underwent a temperature ramp (UP), where ambient temperature increased from a thermoneutral value (28.8 ± 0.3°C) to 37.5 ± 0.6°C. During UP, core and skin temperature, water loss, cardiovascular parameters, skin blood flow and energy expenditure were measured. Three intervals were selected to compare data before and after PMHA: baseline (minutes 30-55: 28.44 ± 0.21°C), T1 (minutes 105-115: 33.29 ± 0.4°C) and T2 (minutes 130-140: 35.68 ± 0.61°C). After 7 d of PMHA, core (T1: −0.13 ± 0.13°C, P = 0.011; T2: −0.14 ± 0.15°C, P = 0.026) and proximal skin temperature (T1: −0.22 ± 0.29°C, P = 0.029) were lower during UP, whereas distal skin temperature was higher in a thermoneutral state (baseline: +0.74 ± 0.77°C, P = 0.009) and during UP (T1: +0.49 ± 0.76°C, P =.057 (not significant), T2:+0.51 ± 0.63°C, P =.022). Moreover, water loss was reduced (−30.5 ± 33.3 ml, P = 0.012) and both systolic (−7.7 ± 7.7 mmHg, P = 0.015) and diastolic (−4.4 ± 4.8 mmHg, P = 0.001) blood pressures were lowered in a thermoneutral state. During UP, only systolic blood pressure was decreased (T2: −6.1 ± 4.4 mmHg, P = 0.003). Skin blood flow was significantly decreased at T1 (−28.35 ± 38.96%, P = 0.037), yet energy expenditure remained unchanged. In conclusion, despite the mild heat stimulus, we show that PMHA induces distinct thermophysiological adaptations leading to increased resilience to heat. [ABSTRACT FROM AUTHOR]

Aim: Higher winter mortality in elderly has been associated with augmented systolic blood pressure (SBP) response and with impaired defense of core temperature. Here we investigated whether the augmented SBP upon mild cold exposure remains after a rewarming period, and whether SBP changes are linked to thermoregulation. Therefore, we tested the following hypotheses: cold-induced increase in SBP (1) remains augmented after rewarming in elderly compared to young adults (2) is related to non-shivering thermogenesis (NST) upon mild cold (3) is related to vasoconstriction upon mild cold. Methods: Blood pressure, energy expenditure (EE), skin and core temperature, skin perfusion (abdomen, forearm, both sides of hand) and % body fat were measured in 12 young adults (Y) and 12 elderly (E). Supine subjects were exposed to a thermoneutral baseline 0.5 h ( Tair = 30.1 °C), 1 h mild cold ( Tair = 20.7 °C), 1 h rewarming ( Tair = 34.8 °C) and 1 h baseline ( Tair = 30.5 °C). Results: Upon mild cold only the young adults showed significant NST (Y: +2.5 ± 0.6 W m−2, P < 0.05). No significant age effects in vasoconstriction were observed. After rewarming per cent change in SBP (%ΔSBP) remained significantly increased in both age groups and was augmented in elderly (Y: +5.0% ± 1.2% vs. E: +14.7% ± 3.1%, P < 0.05). Regression analysis revealed that %ΔSBP significantly related to ΔEE upon mild cold ( P < 0.01, r2 = 0.35) and in elderly also to %body fat ( P < 0.02, r2 = 0.57). Conclusion: Individual changes in SBP after rewarming correlate negatively to NST. Elderly did not show NST, which explains the greater SBP increase in this group. In elderly a relatively large %body fat protected against the adverse effects of mild cold. [ABSTRACT FROM AUTHOR]

During mild cold exposure, elderly are at risk of hypothermia. In humans, glabrous skin at the hands is well adapted as a heat exchanger. Evidence exists that elderly show equal vasoconstriction due to local cooling at the ventral forearm, yet no age effects on vasoconstriction at hand skin have been studied. Here, we tested the hypotheses that at hand sites (a) elderly show equal vasoconstriction due to local cooling and (b) elderly show reduced response to noradrenergic stimuli. Skin perfusion and mean arterial pressure were measured in 16 young adults (Y: 18-28 years) and 16 elderly (E: 68-78 years). To study the effect of local vasoconstriction mechanisms local sympathetic nerve terminals were blocked by bretylium (BR). Baseline local skin temperature was clamped at 33 degrees C. Next, local temperature was reduced to 24 degrees C. After 15 min of local cooling, noradrenaline (NA) was administered to study the effect of neural vasoconstriction mechanisms. No significant age effect was observed in vasoconstriction due to local cooling at BR sites. After NA, vasoconstriction at the forearm showed a significant age effect; however, no significant age effect was found at the hand sites. [Change in CVC (% from baseline): Forearm Y: -76 +/- 3 vs. E: -60 +/- 5 (P < 0.01), dorsal hand Y: -74 +/- 4 vs. E: -72 +/- 4 (n.s.), ventral hand Y: -80 +/- 7 vs. E: -70 +/- 11 (n.s.)]. In conclusion, in contrast to results from the ventral forearm, elderly did not show a blunted response to local cooling and noradrenaline at hand skin sites. This indicates that at hand skin the noradrenergic mechanism of vasoconstriction is maintained with age. [ABSTRACT FROM AUTHOR]

Hypoxia can affect perception of temperature stimuli by impeding thermoregulation at a neural level. Whether this impact on the thermoregulatory response is solely due to affected thermoregulation is not clear, since reaction time may also be affected by hypoxia. Therefore, we studied the effect of hypoxia on thermal perception thresholds for warmth and cold. Thermal perception thresholds were determined in 11 healthy overweight adult males using two methods for small nerve fibre functioning: a reaction-time inclusive method of limits (MLI) and a reaction time exclusive method of levels (MLE). The subjects were measured under normoxic and hypoxic conditions using a cross-over design. Before the thermal threshold tests under hypoxic conditions were conducted, the subjects were acclimatized by staying 14 days overnight (8 h) in a hypoxic tent system (Colorado Altitude Training: 4,000 m). For normoxic measurements the same subjects were not acclimatized, but were used to sleep in the same tent system. Measurements were performed in the early morning in the tent. Normoxic MLI cold sensation threshold decreased significantly from 30.3 +/- 0.4 (mean +/- SD) to 29.9 +/- 0.7 degrees C when exposed to hypoxia (P < 0.05). Similarly, mean normoxic MLI warm sensation threshold increased from 34.0 +/- 0.9 to 34.5 +/- 1.1 degrees C (P < 0.05). MLE measured threshold for cutaneous cold sensation was 31.4 +/- 0.4 and 31.2 +/- 0.9 degrees C under respectively normoxic and hypoxic conditions (P > 0.05). Neither was there a significant change in MLE warm threshold comparing normoxic (32.8 +/- 0.9 degrees C) with hypoxic condition (32.9 +/- 1.0 degrees C) (P > 0.05). Exposure to normobaric hypoxia induces slowing of neural activity in the sensor-to-effector pathway and does not affect cutaneous sensation threshold for either warmth or cold detection. [ABSTRACT FROM AUTHOR]