1. Measured maternal prepregnancy anthropometry and newborn DNA methylation.
- Author
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Yeung EH, Guan W, Mumford SL, Silver RM, Zhang C, Tsai MY, and Schisterman EF
- Subjects
- Adult, Cell-Free Nucleic Acids genetics, Female, Humans, Infant, Newborn blood, Male, Randomized Controlled Trials as Topic, Body Mass Index, DNA Methylation, Epigenesis, Genetic, Obesity genetics
- Abstract
Aim: We examined maternal prepregnancy anthropometry and cord blood DNA methylation., Methods: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons., Results: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10
-8 ). A suggestive association (p < 10-6 ) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults., Conclusion: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.- Published
- 2019
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