1. The magnitude of weight loss induced by metformin is independently associated with BMI at baseline in newly diagnosed type 2 diabetes: Post-hoc analysis from data of a phase IV open-labeled trial.
- Author
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Zhou L, Cai X, Yang W, Han X, and Ji L
- Subjects
- Adult, Aged, Glycated Hemoglobin analysis, Humans, Lipids blood, Metformin adverse effects, Middle Aged, Prospective Studies, Body Mass Index, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents therapeutic use, Metformin therapeutic use, Weight Loss drug effects
- Abstract
Background: The impact of metformin on body weight is variable in T2DM patients among studies. The reasons for the discrepancies are still unknown., Objectives: We aimed to find out the possible predictive factors of weight change induced by metformin based on an analysis of a phase IV open-labeled trial., Material and Methods: We performed a sub-analysis from a prospective, multi-center phase IV open-labeled study in which 371 Chinese newly-diagnosed type 2 diabetes patients received 16 weeks' extended-release metformin monotherapy. The clinical characteristics including weight and laboratory assessments of subjects were collected every 4 weeks. The weight changes from baseline to week 4, 8, 12 and 16 were calculated respectively. The patients were divided into 4 groups by quartile statistics method according to magnitudes of weight change., Results: Of 371 enrolled patients, 324 patients had the weight records from baseline to week 16. The weight decreased gradually with each visit (p < 0.001) and the average weight loss was 2 kg after 16 weeks' treatment of metformin. The patients with higher BMI and bigger waist circumference at baseline showed a more pronounced weight loss. However, the magnitudes of weight loss were independently associated with BMI at baseline only., Conclusions: Metformin can lead to weight loss gradually in newly-diagnosed type 2 diabetes patients. The magnitude of weight loss was independently and only associated with baseline BMI.
- Published
- 2017
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