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5 results on '"Forziato, C"'

1. Childhood obesity classification systems and cardiometabolic risk factors: a comparison of the Italian, World Health Organization and International Obesity Task Force references.

Author

Valerio G, Balsamo A, Baroni MG, Brufani C, Forziato C, Grugni G, Licenziati MR, Maffeis C, Miraglia Del Giudice E, Morandi A, Pacifico L, Sartorio A, and Manco M

Subjects
Adolescent, Advisory Committees, Blood Glucose, Child, Child, Preschool, Cholesterol, LDL blood, Consensus, Female, Humans, Hypertension, Italy epidemiology, Male, Overweight classification, Overweight diagnosis, Pediatric Obesity epidemiology, Prevalence, Reference Values, Risk Factors, Societies, Medical, Triglycerides blood, World Health Organization, Body Mass Index, Pediatric Obesity classification, Pediatric Obesity diagnosis
Abstract

Background: Body Mass Index Italian reference data are available for clinical and/or epidemiological use, but no study compared the ability of this system to classify overweight and obesity and detect subjects with clustered cardiometabolic risk factors with international standards. Therefore our aim was to assess 1) the agreement among the Italian Society for Pediatric Endocrinology and Diabetology (ISPED), the World Health Organisation (WHO) and the International Obesity Task Force (IOTF) Body Mass Index cut-offs in estimating overweight or obesity in children and adolescents; 2) the ability of each above-mentioned set of cut-points to detect subjects with cardiometabolic risk factors., Methods: Data of 6070 Italian subjects aged 5-17 years were collected. Prevalence of normal-weight, overweight and obesity was determined using three classification systems: ISPED, WHO and IOTF. High blood pressure, hypertriglyceridemia, low high density lipoprotein-cholesterol and impaired fasting glucose were considered as cardiometabolic risk factors., Results: ISPED and IOTF classified more subjects as normal-weight or overweight and less subjects as obese as compared to WHO (p <0.0001) in the whole sample and in groups divided by gender and age. The strength of agreement between the three methods compared to each other was excellent for overweight (including obesity) definition (k > 0.900), while it differed for obesity definition, ranging from the highest agreement between ISPED and IOTF (k 0.875) to the lowest between ISPED and WHO (k 0.664). WHO had the highest sensitivity, while ISPED and IOTF systems had the highest specificity, in identifying obese subjects with clustered cardiometabolic risk factors. Analogous results were found in subjects stratified by gender or age., Conclusions: ISPED and IOTF systems performed similarly in assessing overweight and obesity, and were more specific in identifying obese children/adolescents with clustered cardiometabolic risk factors; on the contrary, the WHO system was more sensitive. Given the seriousness of the obesity epidemic, we wonder whether the WHO system should be preferable to the national standards for clinical practice and/or obesity screening.

Published
2017
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2. Central adiposity and left ventricular mass in obese children.

Author

Di Bonito, P., Capaldo, B., Forziato, C., Sanguigno, E., Di Fraia, T., Scilla, C., Cavuto, L., Saitta, F., Sibilio, G., and Moio, N.

Abstract

Abstract: Aim: The impact of central adiposity on left ventricular (LV) mass in childhood obesity has been little explored. This study evaluates whether central obesity influences LV mass and function in obese children. Methods and results: Biochemical, anthropometric and echocardiographic measurements were taken in obese (n =111, mean age 10.6±2.5 years) and non-obese children (n =30, mean age 10.8±3.0 years). Left ventricular function was analyzed by conventional and tissue Doppler echocardiography. LV mass was calculated according to the Penn convention and indexed for height2.7 (LVMi). The obese group showed increased levels of LVMi as compared to the non-obese group (35.7±8.5 vs 23.5±2.8g/h2.7, p <0.0001). Among obese children, we observed a significant increase of LVMi across tertile of waist–height ratio (WHtR). The subjects identified by the highest tertile of WHtR, as compared to subjects identified by the lowest tertile, showed higher levels of BMI (29.5±5.4 vs 31.0±5.0kg/m2, p <0.0001) and LVMi (32.1±6.5 vs 37.1±8.5g/h2.7, p <0.01). Among obese children a positive correlation (standardized for age and gender) was found between LVMi and BMI (r =0.282, p <0.01) and WHtR (r =0.334, p <0.0001). To analyze the independent predictors of LVMi, a stepwise linear regression analysis was performed using age, gender, BMI, blood pressure, heart rate, HOMA-IR and WHtR as independent variables. LVMi was independently associated only with WHtR (β =0.309, t =3.238, p =0.002). Conclusion: Obese children show an increased LVMi and a preserved LV function. Central adiposity is the major determinant of left ventricular mass. [Copyright &y& Elsevier]

Published
2008
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3. Elevated blood pressure, cardiometabolic risk and target organ damage in youth with overweight and obesity

Author

Claudia Forziato, Lucia Pacifico, Anita Morandi, Melania Manco, Giuseppina Campana, Claudio Maffeis, Emanuele Miraglia del Giudice, Giuliana Valerio, Giovanni de Simone, Claudio Chiesa, Sandro Loche, Marco Giorgio Baroni, Maria Rosaria Licenziati, Luisa Gilardini, Nicola Moio, Gianluca Tornese, Procolo Di Bonito, Anna Di Sessa, Di Bonito, P., Pacifico, L., Licenziati, M. R., Maffeis, C., Morandi, A., Manco, M., del Giudice, E. M., Di Sessa, A., Campana, G., Moio, N., Baroni, M. G., Chiesa, C., De Simone, G., Valerio, G., Forziato, C., Gilardini, L., Loche, S., and Tornese, G.

Subjects
Carotid Artery Diseases, Male, Pediatric Obesity, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Left ventricular ma, Liver steatosis, Medicine (miscellaneous), Blood Pressure, 030204 cardiovascular system & hematology, Overweight, Adolescents, Body Mass Index, Left ventricular mass, Prehypertension, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, Carotid intima media thickness, Prevalence, Child, Children, Carotid intima media thickne, education.field_of_study, Nutrition and Dietetics, Age Factors, Left Ventricular, Italy, Cardiovascular Diseases, Child, Preschool, Liver steatosi, Elevated blood pressure, Obesity, Adolescent, Cross-Sectional Studies, Female, Humans, Hypertrophy, Left Ventricular, Insulin Resistance, Risk Assessment, medicine.symptom, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Population, 030209 endocrinology & metabolism, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Preschool, education, business.industry, Hypertrophy, medicine.disease, Blood pressure, business, Body mass index
Abstract

Background and aim: To compare cardiometabolic risk profile and preclinical signs of target organ damage in youth with normal and elevated blood pressure (BP), according to the American Academy of Pediatrics (AAP) guidelines. Methods and results: This cross-sectional multicenter study included 2739 youth (5-17 year-old; 170 normal-weight, 610 overweight and 1959 with obesity) defined non hypertensive by the AAP guidelines. Anthropometric, biochemical and liver ultrasound data were available in the whole population; carotid artery ultrasound and echocardiographic assessments were available respectively in 427 and 264 youth. Elevated BP was defined as BP >= 90th to = 120/80 to

Published
2020
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4. Cardiometabolic Phenotype in Children with Obesity

Author

Nicola Moio, Procolo Di Bonito, Eduardo Sanguigno, Giovanni de Simone, Luigi Cavuto, Claudia Forziato, Brunella Capaldo, Gerolamo Sibilio, Di Bonito, P, Moio, N, Sibilio, G, Cavuto, L, Sanguigno, E, Forziato, C, DE SIMONE, Giovanni, and Capaldo, Brunella

Subjects
Blood Glucose, Male, medicine.medical_specialty, Waist, Heart Ventricles, Blood Pressure, Left ventricular hypertrophy, Body Mass Index, Internal medicine, medicine, Humans, Obesity, cardiovascular diseases, Child, Ultrasonography, Waist-to-height ratio, Waist-Height Ratio, Ventricular Remodeling, medicine.diagnostic_test, business.industry, Anthropometry, medicine.disease, Phenotype, Blood pressure, Endocrinology, Child, Preschool, Obesity, Abdominal, Pediatrics, Perinatology and Child Health, Female, Hypertrophy, Left Ventricular, Waist Circumference, Lipid profile, business, Body mass index
Abstract

To investigate the anthropometric and metabolic correlates of different patterns of left ventricular (LV) geometry in a cohort of outpatient children with high prevalence of obesity.Anthropometric measures, lipid profile, blood pressure (BP), fasting plasma glucose (FPG), and echocardiographic variables were evaluated in 281 white children (6-16 years), of whom 105 were obese and 105 were morbidly obese. Patterns of LV geometry were defined as follows: normal geometry, eccentric LV hypertrophy (LVH), concentric LV remodeling, and concentric LVH.One hundred forty-eight children exhibited normal LV geometry, 53 eccentric LVH, 36 concentric LV remodeling, and 44 concentric LVH. The 4 groups differed in body mass index, waist circumference, waist-to-height ratio, triglycerides/high-density lipoprotein cholesterol ratio (Tg/HDL-C), and BP (P.05-.0001). A statistically significant impairment of diastolic function (expressed as greater E/E', P.002) was observed across patterns of LV geometry. Among anthropometric measures, waist-to-height ratio showed better performance in relation to LVH, with an optimal cut-point of 0.58, compared with body mass index and waist circumference. Children with concentric LVH exhibited the worst metabolic risk profile, with greater prevalence of visceral obesity, high Tg/HDL-C, high BP, and high-normal FPG, than children with normal LV geometry.In children with high levels of obesity, an unfavorable "cardiometabolic phenotype" can be identified, which includes concentric LVH, visceral obesity, high BP, high Tg/HDL-C, and high-normal FPG.

Published
2014
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5. Central adiposity and left ventricular mass in obese children

Author

G. Sibilio, P. Di Bonito, Nicola Moio, Claudia Forziato, Carolina Scilla, Eduardo Sanguigno, T. Di Fraia, Luigi Cavuto, Francesco Saitta, Brunella Capaldo, Di Bonito, P, Capaldo, Brunella, Forziato C, Sanguigno, E, Di Fraia, T, Scilla, C, Cavuto, L, Saitta, F, Sibilio, G, and Moio, N.

Subjects
Male, medicine.medical_specialty, Adolescent, Systole, Endocrinology, Diabetes and Metabolism, Diastole, Medicine (miscellaneous), Ventricular Function, Left, Childhood obesity, Body Mass Index, Tissue Doppler echocardiography, Internal medicine, medicine, Humans, Child, Adiposity, Waist-to-height ratio, Nutrition and Dietetics, business.industry, Stepwise regression, medicine.disease, Endocrinology, Blood pressure, Cardiology, Female, Hypertrophy, Left Ventricular, Cardiology and Cardiovascular Medicine, business, Body mass index
Abstract

The impact of central adiposity on left ventricular (LV) mass in childhood obesity has been little explored. This study evaluates whether central obesity influences LV mass and function in obese children.Biochemical, anthropometric and echocardiographic measurements were taken in obese (n=111, mean age 10.6+/-2.5 years) and non-obese children (n=30, mean age 10.8+/-3.0 years). Left ventricular function was analyzed by conventional and tissue Doppler echocardiography. LV mass was calculated according to the Penn convention and indexed for height(2.7) (LVM(i)). The obese group showed increased levels of LVM(i) as compared to the non-obese group (35.7+/-8.5 vs 23.5+/-2.8 g/h(2.7), p0.0001). Among obese children, we observed a significant increase of LVM(i) across tertile of waist-height ratio (WHtR). The subjects identified by the highest tertile of WHtR, as compared to subjects identified by the lowest tertile, showed higher levels of BMI (29.5+/-5.4 vs 31.0+/-5.0 kg/m(2), p0.0001) and LVM(i) (32.1+/-6.5 vs 37.1+/-8.5 g/h(2.7), p0.01). Among obese children a positive correlation (standardized for age and gender) was found between LVM(i) and BMI (r=0.282, p0.01) and WHtR (r=0.334, p0.0001). To analyze the independent predictors of LVM(i), a stepwise linear regression analysis was performed using age, gender, BMI, blood pressure, heart rate, HOMA-IR and WHtR as independent variables. LVM(i) was independently associated only with WHtR (beta=0.309, t=3.238, p=0.002).Obese children show an increased LVM(i) and a preserved LV function. Central adiposity is the major determinant of left ventricular mass.

Published
2008
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