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Aim: The study aim was to investigate the predictive role of obesity on clinical response following non‐surgical periodontal therapy in individuals with severe periodontitis. Methods: A total of 57 BMI obese and 58 BMI normal non‐smoker adults with periodontitis (defined as probing pocket depths (PPD) of ≥5 mm and alveolar bone loss of >30% with >50% of the teeth affected) received non‐surgical periodontal therapy. Periodontal status was based upon PPD, clinical attachment level (CAL) and full‐mouth bleeding score (FMBS). Mean PPD, percentage sites PPD >4 mm, percentage sites PPD >5 mm and FMBS at 2 and 6 months were outcome variables. Propensity score analysis was used to assess the effect of obesity on outcome variables after adjusting for confounders. Results: Statistically significant higher clinical measures (mean PPD, mean percentage of sites with PPD >4 mm, mean percentage of sites with PPD >5 mm and FMBS) were observed in the obese group than the normal group at baseline, 2 and 6 months after therapy (p <.01). At 2 and 6 months, obesity was associated with worse mean PPD (p <.05), percentage sites with PPD >4 mm (p <.05), percentage sites with PPD > 5mm (p <.05) and FMBS (p <.01), independent of age, gender, ethnicity or plaque levels. Conclusions: Obesity compared to normal BMI status was an independent predictor of poorer response following non‐surgical periodontal therapy. [ABSTRACT FROM AUTHOR]

Objective To investigate periodontitis as a co-morbidity of overweight/obesity in an age-matched sample of periodontitis cases or periodontally healthy controls. Methods Participants were periodontally assessed using whole mouth clinical periodontal measures. Multivariable conditional logistic regression was used to calculate the odds ratio for diagnosis of periodontitis when body mass index (kg/m2), overweight ( BMI 25-29.99 kg/m2, or obese BMI ≥ 30 kg/m2) were the explanatory variables. A receiver operating characteristic ( ROC) curve was generated of all possible BMI (kg/m2) cut-off points discriminating individuals for diagnosis of periodontitis. Results The study comprised 286 participants. BMI showed a dose-response association with increased odds (1.12 per increase of 1 kg/m2, 95% CI 1.05-1.20, p = 0.001) of being a case compared to a control independent of gender, ethnicity, smoking status and dental plaque level. Similarly overweight/obese were independently associated with increased odds of diagnosis of periodontitis for overweight ( OR = 2.56, 95% CI 1.210-5.400, p = 0.014) and for obese ( OR = 3.11, 95% CI 1.052-6.481, p = 0.015) compared to normal weight individuals. The ROC curve analysis confirmed diagnosis of periodontitis was 1.6 times more likely in an individual with the BMI ≥ 24.32 kg/m2. Conclusions Overweight/obese individuals are more likely to suffer from periodontitis compared to normal weight individuals in this case-control sample. [ABSTRACT FROM AUTHOR]