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We aimed to investigate whether first and second-trimester prenatal screening test parameters may be useful in predicting HELLP Syndrome. HELLP syndrome was defined according to Sibai criteria. The collected data were as follows; age, gravida, parity, body mass index, gestational week at labor, route of delivery, birth weight, aspartate aminotransferase (AST), Lactate dehydrogenase (LDH), bilirubin, first trimester multiple of medians (MOM) of pregnancy-associated plasma protein-A (PAPP-A) and Beta human chorionic gonadotropin (B hCG), second trimester B hCG, unconjugated estriol (uE3) and AFP levels were measured. A total of 80 patients in the study group and 135 patients in control groups were included in the study. All the markers of HELLP syndrome were significantly higher in the study group due to the markers was the criteria for HELLP syndrome. While first-trimester PAPP-A was significantly lower in the study group, B hCG levels were similar between groups. The second trimester B hCG level was significantly higher in the study group. AFP level and uE3 level were not different in the control and study groups. Low PAPP-A levels and high second trimester B hCG levels may be associated with HELLP syndrome in subsequent gestational weeks. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of maternal body mass index (BMI) and total weight gain during the pregnancy (WGDP) on all stages of labor. Material and Methods: This is a prospective case-control study carried out at a tertiary referral hospital during 1-year period of time. We divided study population into 4 groups according to BMI and classified women according to WGDP; inadequate, optimum, excessive. Then we assessed the maternal characteristics, cesarean rate, all variables of labor stages, delivery complications, operative delivery rates, and interventions such as; induction rate and episiotomy. Results: A total of 523 women were included in the study [n=55 (10.5%) cesarean section and n=468 (89.5%) vaginal delivery]. There were 435 pregnant Turkish women and 88 Syrian Refugees in the study population. Younger maternal age and need for episiotomy was more common in low-weight group than others. All stages of labor except transition stages (duration between 7 and 10 cm of cervical dilatation) was longer in obese group (222.9±35.6 min, 195.8±29.6 min, 200.6±30.4 min, 255.8±38.2 min in group 1,2,3 and 4, respectively) (p<0.05). We found no statistically significant effect of weight gain on the duration of labor. Conclusion: Either low and high pre-gestational BMI are found to lead to increased risk of adverse labor results in compatible with literature. Therefore, professionals should support weight loss or gain to achieve optimal BMI in women planning pregnancy. [ABSTRACT FROM AUTHOR]