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Water hyacinth (WH) is an invasive plant that generates adverse effects in water bodies, which, when removed, becomes a lignocellulosic residue that would use for methane production. The present investigation aimed to assess the increase in methane production when are applied and combined the pretreatments: grinding, chemical (pH adjust), thermal (temperature control), and concentration control, in anaerobic digestion (AD) through the biochemical methane potential (BMP) test, developed and based on a Taguchi L8 orthogonal arrangement. The results obtained from this study revealed that combined pretreatment has a positive effect on increasing methane production, concerning test control of WH chopped unpretreated, and achieving an increase of 260% to the better conditions (concentration of 30 g CODL−1, pH of 8.5, grinding with a disc mill, and a temperature of 40 °C, for 30 min). The degradation kinetic constant for the best combination of pretreatments as a function of volatile solids (VS) consumption and time was 0.0032 day−1, and the methane production kinetic constant was 0.17 day−1, with a yield of 111 NmL CH4 g VS−1 (equivalent to 0.02856 kg CH4 kg WH−1), and generation potential of 5712 kg of CH4 ha−1 year−1. [ABSTRACT FROM AUTHOR]