1. Near Infrared-Activatable Biomimetic Nanoplatform for Tumor-Specific Drug Release, Penetration and Chemo-Photothermal Synergistic Therapy of Orthotopic Glioblastoma.
- Author
-
Li M, Zhang X, Zhou Y, Chu Y, Shen J, Cai Y, and Sun X
- Subjects
- Animals, Humans, Cell Line, Tumor, Mice, Irinotecan pharmacokinetics, Irinotecan chemistry, Irinotecan pharmacology, Peptides chemistry, Peptides pharmacology, Peptides pharmacokinetics, Infrared Rays, Biomimetic Materials chemistry, Biomimetic Materials pharmacokinetics, Biomimetic Materials pharmacology, Drug Delivery Systems methods, Macrophages drug effects, Macrophages metabolism, Mice, Nude, Combined Modality Therapy methods, Glioblastoma therapy, Glioblastoma drug therapy, Glioblastoma metabolism, Indocyanine Green chemistry, Indocyanine Green pharmacokinetics, Indocyanine Green pharmacology, Brain Neoplasms therapy, Brain Neoplasms drug therapy, Brain Neoplasms metabolism, Nanoparticles chemistry, Photothermal Therapy methods, Blood-Brain Barrier drug effects, Blood-Brain Barrier metabolism, Drug Liberation
- Abstract
Introduction: Glioblastoma multiforme (GBM), a highly invasive and prognostically challenging brain cancer, poses a significant hurdle for current treatments due to the existence of the blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions., Methods: We present a biomimetic nanoplatform with angiopep-2-modified macrophage membrane, loaded with indocyanine green (ICG) templated self-assembly of SN38 (AM-NP), facilitating active tumor targeting and effective blood-brain barrier penetration through specific ligand-receptor interaction., Results: Upon accumulation at tumor sites, these nanoparticles achieved high drug concentrations. Subsequent combination of laser irradiation and release of chemotherapy agent SN38 induced a synergistic chemo-photothermal therapy. Compared to bare nanoparticles (NPs) lacking cell membrane encapsulation, AM-NPs significantly suppressed tumor growth, markedly enhanced survival rates, and exhibited excellent biocompatibility with minimal side effects., Conclusion: This NIR-activatable biomimetic camouflaging macrophage membrane-based nanoparticles enhanced drug delivery targeting ability through modifications of macrophage membranes and specific ligands. It simultaneously achieved synergistic chemo-photothermal therapy, enhancing treatment effectiveness. Compared to traditional treatment modalities, it provided a precise, efficient, and synergistic method that might have contributed to advancements in glioblastoma therapy., Competing Interests: The authors declare no competing interests in this work., (© 2024 Li et al.)
- Published
- 2024
- Full Text
- View/download PDF