1. Translation from Preclinical Research to Clinical Trials: Transdermal Drug Delivery for Neurodegenerative and Mental Disorders.
- Author
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Nguyen-Thi PT, Vo TK, Le HT, Nguyen NTT, Nguyen TT, and Van Vo G
- Subjects
- Humans, Animals, Translational Research, Biomedical methods, Clinical Trials as Topic, Skin metabolism, Skin Absorption, Administration, Cutaneous, Neurodegenerative Diseases drug therapy, Neurodegenerative Diseases metabolism, Mental Disorders drug therapy, Blood-Brain Barrier metabolism, Drug Delivery Systems methods
- Abstract
Neurodegenerative diseases (NDs), particularly dementia, provide significant problems to worldwide healthcare systems. The development of therapeutic materials for various diseases has a severe challenge in the form of the blood-brain barrier (BBB). Transdermal treatment has recently garnered widespread favor as an alternative method of delivering active chemicals to the brain. This approach has several advantages, including low invasiveness, self-administration, avoidance of first-pass metabolism, preservation of steady plasma concentrations, regulated release, safety, efficacy, and better patient compliance. Topics include the transdermal method for therapeutic NDs, their classification, and the mechanisms that allow the medicine to enter the bloodstream through the skin. The paper also discusses the obstacles and potential outcomes of transdermal therapy, emphasizing the benefits and drawbacks of different approaches., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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