1. Effects of salmon calcitonin on plasma renin activity and systolic blood pressure in the rat.
- Author
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Clementi G, Rapisarda E, Fiore CE, Prato A, Amico-Roxas M, Millia C, Bernardini R, Maugeri S, and Scapagnini U
- Subjects
- Animals, Calcitonin administration & dosage, Dinoprostone, Epoprostenol urine, Injections, Intramuscular, Injections, Intravenous, Injections, Intraventricular, Male, Prostaglandins E urine, Rats, Rats, Inbred Strains, Blood Pressure drug effects, Calcitonin pharmacology, Renin blood
- Abstract
Salmon calcitonin, centrally injected, increased plasma renin activity and blood pressure in rats. It is possible that the peptide through an action on the central serotonergic tone stimulated plasma renin activity with subsequent enhancement of blood pressure. Conversely, peripheral administration of the peptide increased plasma renin activity but did not cause changes in blood pressure. Probably, the enhancement of renin may be a physiological response to the renal activity of calcitonin; however, this activity does not seem to involve urinary prostaglandins.
- Published
- 1986
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