1. The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study.
- Author
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Hofmeyr GJ, Seuc AH, Betrán AP, Purnat TD, Ciganda A, Munjanja SP, Manyame S, Singata M, Fawcus S, Frank K, Hall DR, Cormick G, Roberts JM, Bergel EF, Drebit SK, Von Dadelszen P, and Belizan JM
- Subjects
- Adult, Argentina, Double-Blind Method, Female, Humans, Pregnancy, Risk Assessment, South Africa, Treatment Outcome, World Health Organization, Zimbabwe, Blood Pressure drug effects, Blood Pressure Determination methods, Bone Density Conservation Agents administration & dosage, Calcium, Dietary administration & dosage, Pre-Eclampsia prevention & control, Pregnancy Complications, Cardiovascular prevention & control
- Abstract
Background: Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP)., Methods: This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24weeks after randomization were included., Results: Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6mmHg) was statistically larger than in the placebo group (+0.8mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p=0.025). The effect of calcium on diastolic BP at 12weeks was greater than in those with non-severe pre-eclampsia (p=0.020, ANOVA analysis)., Conclusions: There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution., (Copyright © 2015. Published by Elsevier B.V.)
- Published
- 2015
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