1. Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness
- Author
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Chen, Zheng-Wei, Pan, Chien-Ting, Tsai, Cheng-Hsuan, Chang, Yi-Yao, Chang, Chin-Chen, Lee, Bo-Ching, Chiu, Yu-Wei, Huang, Wei-Chieh, Lin, Yu-Li, Wu, Vin-Cent, Hung, Chi-Sheng, Liao, Che-Wei, Lin, Yen-Hung, and Group, on behalf of TAIPAI Study Group on behalf of TAIPAI Study
- Subjects
medicine.medical_specialty ,QH301-705.5 ,Medicine (miscellaneous) ,brachial-ankle pulse wave velocity ,heart-ankle pulse wave velocity ,Essential hypertension ,General Biochemistry, Genetics and Molecular Biology ,Article ,chemistry.chemical_compound ,Primary aldosteronism ,Internal medicine ,medicine ,cardiovascular diseases ,Biology (General) ,Pulse wave velocity ,Aldosterone ,primary aldosteronism ,Receiver operating characteristic ,business.industry ,Wave velocity ,medicine.disease ,Blood pressure ,arterial stiffness ,chemistry ,Arterial stiffness ,Cardiology ,cardiovascular system ,business ,circulatory and respiratory physiology - Abstract
Primary aldosteronism (PA) is associated with higher arterial stiffness compared to essential hypertension (EH). However, few studies have compared different pulse wave velocity (PWV) parameters to detect aldosterone-induced arterial stiffness. In this study, we aimed to compare the sensitivity in detecting aldosterone-induced arterial stiffness between brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV). We prospectively enrolled 1006 PA patients and 983 EH patients. Detailed medical history, basic biochemistry data and two PWV measurements (baPWV and haPWV) were collected in both groups. We performed analysis on the original cohort and two propensity score matching (PSM) models (model 1 adjusted for age and sex, model 2 adjusted for age, sex, systolic and diastolic blood pressure). The DeLong test was used to compare areas under receiver operating characteristic curves (AUCs) between baPWV and haPWV to predict PA. In all models, the PA patients had significantly higher baPWV compared to the EH patients. The AUC of haPWV was greater than that of baPWV. In conclusion, haPWV seems to be a better PWV parameter than baPWV in detecting aldosterone-induced arterial stiffness.
- Published
- 2021