1. Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components
- Author
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Qi-Fang Huang, Lucas S. Aparicio, Lutgarde Thijs, Fang-Fei Wei, Jesus D. Melgarejo, Yi-Bang Cheng, Chang-Sheng Sheng, Wen-Yi Yang, Natasza Gilis-Malinowska, José Boggia, Teemu J. Niiranen, Wiktoria Wojciechowska, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Valérie Tikhonoff, Belen Ponte, Menno Pruijm, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovský, Danuta Czarnecka, Kalina Kawecka-Jaszcz, Antti M. Jula, Murielle Bochud, Thomas Vanassche, Peter Verhamme, Harry A.J. Struijker-Boudier, Ji-Guang Wang, Zhen-Yu Zhang, Yan Li, Jan A. Staessen, LS Aparicio, J Barochiner, L Thijs, JA Staessen, FF Wei, WY Yang, ZY Zhang, YB Cheng, QH Guo, JF Huang, QF Huang, Y Li, CS Sheng, JG Wang, J Filipovský, J Seidlerová, EP Juhanoja, AM Jula, AS Lindroos, TJ Niiranen, SS Sivén, E Casiglia, A Pizzioli, V Tikhonoff, BS Chori, B Danladi, AN Odili, H Oshaju, W Kucharska, K Kunicka, N Gilis-Malinowska, K Narkiewicz, W Sakiewicz, E Swierblewska, K Kawecka-Jaszcz, K Stolarz-Skrzypek, AE Schutte, GR Norton, AJ Woodiwiss, D Ackermann, M Bochud, B Ponte, M Pruijm, R Álvarez-Vaz, C Américo, C Baccino, L Borgarello, L Florio, P Moliterno, A Noboa, O Noboa, A Olascoaga, P Parnizari, M Pécora, RS: Carim - H03 ECM and Wnt signaling, Farmacologie en Toxicologie, IDCARS (International Database of Central Arterial Properties for Risk Stratification) Investigators, Aparicio, L.S., Barochiner, J., Thijs, L., Staessen, J.A., Wei, F.F., Yang, W.Y., Zhang, Z.Y., Cheng, Y.B., Guo, Q.H., Huang, J.F., Huang, Q.F., Li, Y., Sheng, C.S., Wang, J.G., Filipovský, J., Seidlerová, J., Juhanoja, E.P., Jula, A.M., Lindroos, A.S., Niiranen, T.J., Sivén, S.S., Casiglia, E., Pizzioli, A., Tikhonoff, V., Chori, B.S., Danladi, B., Odili, A.N., Oshaju, H., Kucharska, W., Kunicka, K., Gilis-Malinowska, N., Narkiewicz, K., Sakiewicz, W., Swierblewska, E., Kawecka-Jaszcz, K., Stolarz-Skrzypek, K., Schutte, A.E., Norton, G.R., Woodiwiss, A.J., Ackermann, D., Bochud, M., Ponte, B., Pruijm, M., Álvarez-Vaz, R., Américo, C., Baccino, C., Borgarello, L., Florio, L., Moliterno, P., Noboa, A., Noboa, O., Olascoaga, A., Parnizari, P., and Pécora, M.
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Male ,Pulsatile flow ,population ,morbidity ,030204 cardiovascular system & hematology ,DISEASE ,0302 clinical medicine ,030212 general & internal medicine ,610 Medicine & health ,risk ,education.field_of_study ,Hazard ratio ,blood pressure ,Middle Aged ,LOCAL PULSE PRESSURE ,Pulse pressure ,Peripheral ,Cardiovascular Diseases ,Hypertension ,Cardiology ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,mortality ,ARTERIAL STIFFNESS ,Adult ,medicine.medical_specialty ,Population ,ASCENDING AORTIC PRESSURE ,EVENTS ,03 medical and health sciences ,KIDNEY ,Internal medicine ,Internal Medicine ,medicine ,Humans ,education ,Sensitivity analyses ,Aged ,business.industry ,Epidemiology/Population Science ,Blood Pressure Determination ,Original Articles ,Total mortality ,Blood pressure ,Heart Disease Risk Factors ,business - Abstract
Supplemental Digital Content is available in the text., Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, 5.0, 7.3, and 22.0 per 1000 person-years) with comparable estimates for cSBP, pSBP, and pPP. The multivariable-adjusted hazard ratios, expressing the risk per 1-SD increment in BP, were 1.50 (95% CI, 1.33–1.70) for cSBP, 1.36 (95% CI, 1.19–1.54) for cPP, 1.49 (95% CI, 1.33–1.67) for pSBP, and 1.34 (95% CI, 1.19–1.51) for pPP (P
- Published
- 2020
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