1. Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD
- Author
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Chi Ma, Qiong Fu, Laurence P. Diggs, John C. McVey, Justin McCallen, Simon Wabitsch, Benjamin Ruf, Zachary Brown, Bernd Heinrich, Qianfei Zhang, Umberto Rosato, Sophie Wang, Linda Cui, Jay A. Berzofsky, David E. Kleiner, Dale B. Bosco, Long-Jun Wu, Chunwei Walter Lai, Yaron Rotman, Changqing Xie, Firouzeh Korangy, and Tim F. Greten
- Subjects
Blood Platelets ,Mice ,Cancer Research ,Carcinoma, Hepatocellular ,Oncology ,Non-alcoholic Fatty Liver Disease ,CD40 Ligand ,Liver Neoplasms ,Animals ,Receptors, Purinergic P2Y12 - Abstract
Platelets, the often-overlooked component of the immune system, have been shown to promote tumor growth. Non-alcoholic fatty liver disease (NAFLD) is a common disease in the Western world and rising risk for hepatocellular carcinoma (HCC). Unexpectedly, we observed that platelets can inhibit the growth of established HCC in NAFLD mice. Through pharmacological inhibition and genetic depletion of P2Y12 as well as in vivo transfusion of wild-type (WT) or CD40L
- Published
- 2022