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Abstract: The unsteady non-Newtonian blood flow in symmetric stenotic arteries is numerically simulated considering fluid–structure interaction (FSI) using the code ADINA. A two layer hyperelastic anisotropic structural model is used for the compliant arterial wall. The pressure used as outlet boundary condition was obtained running a CFD simulation for each stenosis with a physiologically-realistic time variation of pressure at inlet for different velocities. The obtained pressure drop increases in potential form with the inlet velocity for a fixed stenosis severity. The FSI results show that the maxima velocity and WSS at throat increase in exponential form with stenosis severity. The minimum and maximum effective stress at throat for stenosis severity of S =70% ranged between 47 kPa and 96 kPa at diastole and systole, respectively. [Copyright &y& Elsevier]

Abstract: Hemodynamics plays an important role in the progression and rupture of cerebral aneurysms. The temporal and spatial variations in wall shear stress (WSS) within the aneurysmal sac are hypothesized to be correlated with the growth and rupture of the aneurysm. The current work describes the blood flow dynamics in 34 patient-specific models of saccular aneurysms located in the region of the anterior and posterior circulation of the circle of Willis. The models were obtained from three-dimensional rotational angiography image data and blood flow dynamics was studied under a physiologically representative waveform of inflow. The three-dimensional continuity and momentum equations for unsteady laminar flow were solved with commercial software using non-structured fine grid sizes. The vortex structure, the wall pressure, and the WSS showed large variations, depending on the morphology of the artery, size of the aneurysm, and form. A correlation existed between the mean WSS on the aneurysmal sac for lateral unruptured and ruptured aneurysms with an aneurysm surface index, which is defined as the ratio between the aneurysm area and the artery area at model inlet, respectively. [Copyright &y& Elsevier]

Abstract: In this work the unsteady non-Newtonian blood flow and mass transfer in symmetric and non-symmetric stenotic arteries are numerically simulated considering the fluid-structure interaction (FSI) using the code ADINA. Blood with hyperviscosity syndrome is considered and hyperelastic Mooney–Rivlin model is used for the compliant arterial wall. The inlet boundary condition of imposed velocity or pressure is critical to obtain realistic hemodynamic results in stenotic arteries. The FSI affects significantly the hemodynamics on the stenotic arteries models, the arteries are considerably dilated and compressed due the stenosis. The stenosis severity and geometry have important influence on recirculation length, and distribution of concentration of macromolecules, such as low density lipoproteins (LDL). [Copyright &y& Elsevier]

Abstract: Blood flow dynamics under physiologically realistic pulsatile conditions plays an important role in the growth, rupture and surgical treatment of intracranial aneurysms. This paper describes the flow dynamics and arterial wall interaction in a representative model of a terminal aneurysm of the basilar artery, and compares its wall shear stress, pressure, effective stress and wall deformation with those of a healthy basilar artery. The arterial wall was assumed to be elastic or hyperelastic, isotropic, incompressible and homogeneous. The flow was assumed to be laminar, Newtonian, and incompressible. The fully coupled fluid and structure models were solved with the finite elements package ADINA. The intra-aneurysmal pulsatile flow shows single recirculation region during both systole and diastole. The pressure and shear stress on the aneurysm wall exhibit large temporal and spatial variations. The wall thickness, the Young’s modulus in the elastic wall model and the hyperelastic Mooney–Rivlin wall model affect the aneurysm deformation and effective stress in the wall especially at systole. [Copyright &y& Elsevier]