1. Chronic red blood cell exchange to prevent clinical complications in sickle cell disease
- Author
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Giovanna Oriella Manenti, Francesco Costantino, Francesco Bennardello, Salvatore Calabrese, Pietro Bonomo, Giovanni Garozzo, Carmelo Fidone, Roberto Distefano, Sergio Cabibbo, Agostino Antolino, Simone Travali, and Vincenzo Licitra
- Subjects
Adult ,Male ,Erythrocyte transfusion ,medicine.medical_specialty ,Iron Overload ,Adolescent ,Anemia ,Cell ,Ferritin levels ,Blood Donors ,Disease ,Anemia, Sickle Cell ,Gastroenterology ,Internal medicine ,medicine ,Secondary Prevention ,Humans ,In patient ,Child ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Hematology ,Middle Aged ,medicine.disease ,Red blood cell ,medicine.anatomical_structure ,Immunology ,Female ,business ,Erythrocyte Transfusion - Abstract
We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of sickle cell disease, and if done automatically, reduced iron overload. Ferritin levels also decreased in patients treated with automatic red blood cell exchange. Furthermore, using Single Donor Red Blood Cell units (SDRC) we reduced the potential exposure to transfusion transmitted infectious diseases (TTI).
- Published
- 2005