1. Prevalence of HCV-antibodies and HCV-RNA in donor blood in Tokushima Prefecture.
- Author
-
Honda H, Hibino S, Nii C, Horikita M, Kamamura M, Nishikado T, Horie T, Okahisa T, Shibata H, and Shimizu I
- Subjects
- Adolescent, Adult, Hepatitis C Antibodies, Humans, Incidence, Japan epidemiology, Middle Aged, Blood Donors, Hepacivirus genetics, Hepacivirus immunology, Hepatitis Antibodies blood, RNA, Viral blood
- Abstract
The incidence of C100-3 among the blood specimens qualified for transfusion according to the conventional criteria was 1.1%. The incidence of C100-3 in donor blood in Tokushima Prefecture is not significantly different from that reported for all Japan. Of the donors positive for the conventional screening test and C100-3, 73.6% showed high ALT levels. For all antibodies, the incidence of HCV-RNA was very low in the donors positive for a single antibody, but was high in those positive for multiple antibodies. All of the donors showing the 3 antibodies were positive for HCV-RNA. While a test for multiple antibodies is thought to be effective for the screening of HCV, more blood needs to be discarded, having a serious cost-performance problem. The O.D. value for C100-3 and the 2nd antibody seem to be useful reference value for antibody titers.
- Published
- 1994