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Background and Objectives: Di‐ethyl‐hexyl‐phthalate (DEHP) is currently the main plasticizer used for whole blood collection systems. However, in Europe, after May 2025, DEHP may no longer be used above 0.1% (w/w) in medical devices. DEHP stabilizes red cell membranes, thereby suppressing haemolysis during storage. Here we compared in vitro quality parameters of red cell concentrates (RCCs) collected and stored in DEHP‐, DINCH‐ or DINCH/BTHC‐PVC hybrid blood bags with saline‐adenine‐glucose‐mannitol (SAGM) or phosphate‐adenine‐glucose‐guanosine‐saline‐mannitol (PAGGSM) storage solution. Last, we performed haemovigilance surveillance for RCC collected in DINCH‐PVC and stored in PAGGSM/BTHC‐PVC. Materials and Methods: In vitro quality parameters of RCC were determined during 42 days of storage. Haemovigilance surveillance was conducted to compare the frequency and type of transfusion reaction. Results: Haemolysis levels were increased in SAGM/BTHC‐PVC as compared to SAGM/DEHP‐PVC (0.66% ± 0.18% vs. 0.36% ± 0.17%). PAGGSM storage solution was able to adequately suppress haemolysis to levels observed during storage in SAGM/DEHP‐PVC, both in BTHC‐PVC (0.38% ± 0.12%), and to a slightly lesser extent in DINCH‐PVC (0.48% ± 0.17%). A total of 1650 PAGGSM/BTHC‐PVC and 5662 SAGM/DEHP‐PVC RCC were transfused yielding a transfusion reaction frequency of 0.24% (95% CI 0.0000–0.0048) and 0.44% (95% CI 0.0027–0.0061) respectively. Conclusion: The in vitro quality of RCC stored in PAGGSM/BTHC‐PVC and SAGM/DEHP‐PVC is comparable. There is no indication that transfusion of erythrocytes stored in PAGGSM/BTHC‐PVC results in increased transfusion reaction frequency. These initial results provide a basis for further clinical evaluation to narrow down the confidence interval of transfusion reaction frequency. [ABSTRACT FROM AUTHOR]