1. HHV8-related Castleman disease presenting with nephrotic syndrome and pauci-immune glomerulonephritis: A histological surprise.
- Author
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Urbain, Fanny, Ferlicot, Sophie, Lazure, Thierry, Bafakih, Tarek, Mouawad, Sarah, Lavigne, Arthur, Domnariu, Paul-Albert, Lambotte, Olivier, and Dang, Julien
- Subjects
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FOLLICULAR dendritic cells , *ANTINEUTROPHIL cytoplasmic antibodies , *BLOOD cell count , *CHRONIC hepatitis C , *CASTLEMAN'S disease - Abstract
The letter to the editor published in Leukemia & Lymphoma discusses a rare case of HHV8-related Castleman disease presenting with nephrotic syndrome and pauci-immune glomerulonephritis in a 78-year-old Caucasian man. The patient had a history of chronic hepatitis C and presented with various symptoms, including lymphadenopathy, splenomegaly, edema, and purpuric lesions. Extensive diagnostic work-up led to the diagnosis of multicentric HHV-8+ Castleman disease related pauci-immune systemic vasculitis, and treatment with steroids and Rituximab resulted in significant improvement in the patient's condition. The authors emphasize the importance of considering Castleman disease in the diagnostic work-up of ANCA-negative pauci-immune glomerulonephritis, especially in the presence of tumoral syndrome or cytopenia. [Extracted from the article]
- Published
- 2025
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