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Background: Seizure disorder is a one of major health problem in adults mostly in late adulthood in which chances of seizures are increased especially due to comorbidities like cerebrovascular stroke, CNS infection (tuberculoma, viral encephalitis), degenerative disease of brain, and brain tumor. Materials and methods: We studied 50 adult patients to identify various etiology of seizures. We checked for various parameters like complete blood count, blood sugar level, renal function tests with electrolytes, liver function tests, brain imaging and Electroencephalogram (EEG). Results: With the help of this study, we identify that most common cause for seizure was idiopathic in less than 50 years of age and post stroke epilepsy in more than 50 years of age. Generalized tonic clonic seizure was most common type of seizure. With the help of newer neuro-imaging modalities and EEG it was possible to find out specific etiology of seizure, so EEG and imaging study should be integral part of investigation work of patient with seizure disorder. Conclusion: The present study was an effort to find out the various etiology and type of seizures in adult its types and clinical profile and response to antiepileptic drugs. Every patient should be investigated thoroughly and diagnosed and best suitable drug given depending upon type of seizures to the patient for proper control of seizures and also improve morbidity and mortality due to seizures. [ABSTRACT FROM AUTHOR]