1. Expression and role of ERAP1 in placental tissues of preeclampsia.
- Author
-
Xu, Yanyan, Wu, Junjiao, and Wu, Jianbo
- Subjects
- *
GENE expression , *POLYMERASE chain reaction , *IMMUNOHISTOCHEMISTRY , *CROSS-sectional method , *PREECLAMPSIA , *BLASTOCYST , *PROTEOLYTIC enzymes , *PLACENTA , *CELL lines , *HISTOCOMPATIBILITY antigens - Abstract
Objective: This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis.Methods: ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen).Results: The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia.Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF