1. Assessment of a guideline-based heart substructures delineation in left-sided breast cancer patients undergoing adjuvant radiotherapy : Quality assessment within a randomized phase III trial testing a cardioprotective treatment strategy (SAFE-2014).
- Author
-
Francolini G, Desideri I, Meattini I, Becherini C, Terziani F, Olmetto E, Delli Paoli C, Pezzulla D, Loi M, Bonomo P, Greto D, Calusi S, Casati M, Pallotta S, and Livi L
- Subjects
- Algorithms, Cardiotonic Agents administration & dosage, Chemotherapy, Adjuvant methods, Combined Modality Therapy methods, Drug Therapy, Combination, Echocardiography, Doppler methods, Female, Humans, Observer Variation, Quality Assurance, Health Care, Radiation Injuries diagnostic imaging, Radiometry methods, Reproducibility of Results, Unilateral Breast Neoplasms drug therapy, Bisoprolol administration & dosage, Guideline Adherence, Heart drug effects, Heart radiation effects, Radiation Injuries prevention & control, Radiotherapy, Adjuvant methods, Ramipril administration & dosage, Unilateral Breast Neoplasms radiotherapy
- Abstract
Background and Purpose: In our institute, breast cancer patients undergoing adjuvant treatment are included in a protocol aimed to reduce cardiovascular morbidity (SAFE-2014, NCT2236806), assessing preclinical heart damage with heart speckle-tracking ultrasound. To develop a dose constraint related to subclinical heart damage, a reliable delineation of heart substructures based on a pre-existing guideline was made., Patients and Methods: Heart substructures of 16 left-sided breast cancer patients included in the SAFE protocol were delineated by five operators. For each substructure, a multi-contour delineation based on a majority vote algorithm (MCD) was created. A consensus-based delineation (CBD) was developed by an independent team of two blinded operators. Dice similarity coefficients (DSC) between volumes delineated by different operators and the MCD were collected and reported, as well as DSC between CBD and MCD., Results: Mean DSCs between heart chambers delineated by each operator and the corresponding MCDs ranged between 0.78 and 0.96. Mean DSC between substructures delineated by all single operators and the corresponding MCD ranged between 0.84 and 0.94. Mean DSC between CBD and the corresponding MCD ranged from 0.89 to 0.97., Conclusion: Results showed low inter-observer variability of heart substructure delineation. This constitutes an external validation of the contouring atlas used, allowing a reliable dosimetric assessment of these volumes within the SAFE-2014 trial.
- Published
- 2019
- Full Text
- View/download PDF