1. Cord insulin and C-peptide--distribution in an unselected population.
- Author
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Stanley KP, Fraser RB, Milner M, and Bruce C
- Subjects
- Humans, Infant, Newborn, Neonatal Screening methods, Radioimmunoassay, Birth Weight, C-Peptide blood, Fetal Blood, Insulin blood
- Abstract
Objective: To assess the distribution of cord blood insulin in an unselected population, and examine its relation to birthweight centiles., Setting: District General Hospital in Nottinghamshire., Subjects: 209 unselected singleton births., Mean Outcome Measure: Cord blood insulin; cord blood C-peptide; birthweight centiles., Results: Hyperinsulinaemic babies (greater than 97th centile for cord insulin) were found at all birthweight centiles. 15% of high birthweight babies were hyperinsulinaemic. For low birthweight babies, the distribution of cord insulin/C-peptide was skewed indicating a high number of low values. Hypoinsulinaemic babies were present up to the 50th centile for birthweight., Conclusions: Abnormalities of fetal insulinisation may be found in babies of all birthweights.
- Published
- 1992
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