17 results on '"Schuster, A. K."'
Search Results
2. Hypertensive Retinopathy is Not Associated with Low or High Birth Weight – Results from the Population-Based German Gutenberg Health Study.
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Fieß, Achim, Gißler, Sandra, Wild, Philipp S, Lackner, Karl J, Münzel, Thomas, Michal, Matthias, Urschitz, Michael S, Pfeiffer, Norbert, and Schuster, Alexander K
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LOW birth weight ,FETAL growth retardation ,CARDIOVASCULAR diseases risk factors ,BIRTH weight ,HYPERTENSION - Abstract
This study investigates the association between self-reported birth weight (BW) and the prevalence of hypertensive retinopathy (HR) in a large population-based cohort in Germany, as part of the Gutenberg Health Study (GHS). The study involved analyzing fundus photographs of 6855 participants, aged 35 to 74, to assess signs of HR, classified according to the Mitchell-Wong Classification. The research aimed to explore the correlation between fetal growth restriction indicated by BW and the frequency of HR. The results showed that the frequency of HR did not significantly differ among groups with different BW ranges. In the univariable analysis, HR was initially associated with high BW, but this association disappeared after adjusting for age, sex, and cardiovascular risk factors. No association was found between low BW and HR. The study reveals novel insights as there are no prior population-based studies specifically exploring this association. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Ocular geometry in adults born small, appropriate or large for gestational age at term.
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Fieß, Achim, Schultheis, Anna, Mildenberger, Eva, Urschitz, Michael S., Stoffelns, Bernhard, Pfeiffer, Norbert, and Schuster, Alexander K.
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GESTATIONAL age ,FETAL growth retardation ,FETAL development ,SMALL for gestational age ,BIRTH weight - Abstract
Purpose: Intrauterine growth restriction leading to a birth weight (BW) which is too low for gestational age (GA) is a known risk factor for various altered organ morphologies and dysfunction in later life. This study aimed to determine for the first time the effects of being small (SGA) or large for gestational age (LGA) on the ocular geometry of adults born at term. Methods: All participants were examined with optical biometry (LenStar 900, Haag Streit) to compare the corneal curvature, white‐to‐white distance, anterior chamber depth, lens thickness and axial length between former moderate (BW percentile 3rd to <10th) and severe (BW <3rd percentile) SGA, controls (BW 10th‐90th percentile) and former moderate (BW >90th to 97th percentile) and severe (BW >97th percentile) LGA. Multivariable linear regression was used to analyse associations with GA, BW percentile categories, placental insufficiency, preeclampsia and breastfeeding after adjustment for age and sex. Results: In total, 589 eyes of 296 individuals born at term (aged 30.0 ± 9.4 years, 156 females) were examined, including 40 severe SGA, 38 moderate SGA, 140 with normal BW, 38 moderate LGA and 40 severe LGA. There was an association between a steeper corneal curvature with moderate (B = −0.201; p < 0.001) and severe SGA (B = −0.199; p < 0.001), with extreme SGA associated with smaller white‐to‐white (B = −0.263; p = 0.001) and a shorter axial length (B = −0.524; p = 0.031). Conclusions: Severe and moderate prenatal growth restriction in adults born at term leads to an altered ocular geometry, namely a steepening of the cornea and a smaller corneal diameter. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Association of Birth Weight with Peripapillary Retinal Nerve Fiber Layer Thickness in Adulthood-Results from a Population-Based Study
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Fieß, Achim, Nickels, Stefan, Urschitz, Michael S., Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Lackner, Karl J., Hoffmann, Esther M., Pfeiffer, Norbert, and Schuster, Alexander K.
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anatomy ,Clinical and Epidemiologic Research ,peripapillary retinal nerve fiber layer ,birth weight ,epidemiology ,optic nerve - Abstract
Purpose Low birth weight is associated with altered retinal development in childhood, including reduced peripapillary retinal nerve fiber layer (pRNFL) thickness. However, to the best of our knowledge, no population-based study has analyzed the relationship of low birth weight to pRNFL thickness in adulthood. The purpose of this study was to investigate whether birth weight has a long-term effect on pRNFL thickness in adulthood. Methods In the German population-based Gutenberg Health Study (GHS), participants were examined with spectral-domain optical coherence tomography using a peripapillary scan and automated measurement of pRNFL thickness as a global parameter and in six sectors. The association between self-reported birth weight and the different pRNFL sectors were analyzed with multivariable linear regression, adjusted for potential confounders including sex, age, axial length, self-reported age-related macular degeneration, and glaucoma. Results In 3,028 participants, self-reported birth weight was documented and pRNFL measurements were successfully performed (1632 females, ages 54.9 ± 10.0 years). After adjustment for several confounders in the multivariable model, a positive association was observed between birth weight and pRNFL thickness in the global sector (β = 0.13 µm/100 g; 95% CI, 0.08–0.18; P < 0.001; R2 = 0.007) and especially in the inferotemporal sector (β = 0.22 µm/100 g; 95% CI, 0.15–0.29; P < 0.001; R2 = 0.008) and inferonasal sector (β = 0.28 µm/100 g; 95% CI, 0.17–0.39; P < 0.001; R2 = 0.005). Conclusions Our data show that there is a weak relationship between birth weight and pRNFL thickness in adulthood. This weak association is particularly present in the inferior part of the optic nerve head. Therefore, low birth weight may have an impact on optic nerve head development and potentially on ocular disease development.
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- 2022
5. A lower birth weight percentile is associated with central corneal thickness thinning: Results from the Gutenberg Prematurity Eye Study (GPES).
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Fieß, Achim, Grabitz, Stephanie D., Mildenberger, Eva, Urschitz, Michael S., Fauer, Agnes, Hampel, Ulrike, Wasielica-Poslednik, Joanna, Zepp, Fred, Pfeiffer, Norbert, and Schuster, Alexander K.
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LOW birth weight ,CORNEA ,PRENATAL depression ,VISUAL fields ,FETAL development ,RETROLENTAL fibroplasia ,BIRTH weight - Abstract
Prematurity, prenatal growth restriction, and retinopathy of prematurity (ROP) are associated with altered ocular geometry, such as a steeper corneal shape in childhood, but it is unclear whether perinatal history affects corneal thickness development, so this study investigated whether corneal thickness in adulthood is affected by perinatal history. The Gutenberg Prematurity Eye Study (GPES) is a retrospective cohort study with a prospective ophthalmologic examination in Germany. The corneal thickness was measured by Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany), and the relationship between perinatal parameters respective birth weight percentile and corneal thickness at different locations was assessed using uni- and multivariable linear regression models. Covariates included age, sex, mean corneal radius, white-to-white distance, gestational age, birth weight percentile, ROP occurrence, and treatment. The main outcome measures were corneal thickness at the apex, the pupil center, and the corneal periphery. The corneal thickness was measured in 390 participants (754 eyes, mean age 29.7+/-8.7 years, 224 females). In multivariable analyses, a lower birth weight percentile was associated with a lower corneal thickness at the apex (B = 0.20, p = 0.003) and the pupil (B = 0.19, p = 0.007). These effects diminished towards the corneal periphery and were not observed beyond the 4-mm diameter circle around the thinnest corneal position. Neither gestational age, ROP occurrence, or ROP treatment affected the corneal thickness. A lower birth weight percentile in subjects born preterm as a proxy for restricted fetal growth is associated with corneal thickness thinning in adults aged 18 to 52 years, indicating that corneal thickness development, particularly in the corneal center, may originate in the fetal stage. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Association of birth weight with corneal aberrations in adulthood – Results from a population-based study.
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Fieß, Achim, Urschitz, Michael S., Nagler, Markus, Nickels, Stefan, Marx-Groß, Susanne, Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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BIRTH weight ,LOW birth weight ,CORNEA ,VISION ,ADULTS - Abstract
Low birth weight (BW) is associated with increased corneal aberrations in childhood and alterations of corneal geometry in adulthood. Increased corneal aberrations may be a factor contributing to decreased visual function in former low BW newborns in later life. Hence, the aim of this study was to analyze the long-term effect of low BW on corneal aberrations in adulthood. In the German population-based Gutenberg Health Study (GHS) participants (age: 40–80 years) were examined with Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany). The relationship between self-reported BW and the different types of corneal aberrations was analyzed using linear regression analysis as uni- and multivariable analysis with adjustment for potential confounders. The main outcome measures were corneal aberrations defined as astigmatism (Z 2
−2 ; Z 22 ), coma (Z 3−1 ; Z 31 ), trefoil (Z 3−3 ; Z 33 ), spherical aberration (Z 40 ) and root-mean square of higher order aberrations (HOA; 3rd up to 8th order; aperture size: 6 mm). Overall, 5,628 participants were included in this analysis (3,004 women, aged 56.0 +/- 10.3 years). In a multivariable analysis lower BW was associated with decreased horizontal trefoil (B = 0.004 [0.001; 0.006] µm/500 g; p =.008); higher spherical aberrations (B =-0.006 [-0.008;-0.003] µm/500 g; p <.001), higher RMS (B =-0.028 [-0.042;-0.014] µm/500 g; p <.001), increased HOA (B =-0.007 [-0.010;-0.003] µm/500 g; p <.001) and increased LOA (B =-0.027 [-0.041;-0.013] µm/500 g; p <.001). No association was observed between birth weight and the other types of corneal aberrations in multivariable model. Our results indicate an association between BW and spherical aberration in adults aged 40 to 80 years. This indicates that low BW may have an association with an altered corneal shape development which may affect optical image quality and, hence, visual function. [ABSTRACT FROM AUTHOR]- Published
- 2023
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7. Macular morphology is not affected by low or high birthweight in individuals born at term—Results from the Gutenberg Prematurity Eye Study.
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Fieß, Achim, Gißler, Sandra, Mildenberger, Eva, Urschitz, Michael S., Laspas, Panagotios, Stoffelns, Bernhard, Pfeiffer, Norbert, Hartmann, Alica, and Schuster, Alexander K.
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MORPHOLOGY ,BIRTH weight ,FETAL growth retardation ,SMALL for gestational age ,CHOROID - Abstract
This article discusses the potential impact of low birthweight on macular morphology in individuals born at term. Previous studies have shown that low birthweight is associated with increased foveal thickness in individuals born preterm. However, it is unclear whether this effect is solely due to preterm birth or if it is also influenced by perinatal hypotrophy in individuals born small-for-gestational age (SGA). This study aimed to explore the association between fetal growth restriction in individuals born at term and various macular parameters. The results showed no significant differences in macular morphology between different birthweight groups, suggesting that macular developmental alterations are more likely a consequence of prematurity rather than perinatal growth indicated by birthweight. [Extracted from the article]
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- 2024
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8. Corneal Aberrations and Thickness in Adults Born Small, Appropriate, or Large for Gestational Age at Term.
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Fieß, Achim, Riedl, Jana C., Gißler, Sandra, Mildenberger, Eva, Urschitz, Michael S., Stoffelns, Bernhard, Pfeiffer, Norbert, and Schuster, Alexander K.
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GESTATIONAL age ,SMALL for gestational age ,CORNEA ,LOW birth weight ,FETAL development - Abstract
Highlights: What are the main findings? Restricted prenatal growth is associated with increased higher-order aberrations in adulthood. There was an association between increased higher-order aberrations correlating with lower visual acuity and spherical equivalent. What is the implication of the main finding? These results indicate that corneal development is influenced by fetal growth irrespective of prematurity, leading to life-long alterations of ocular shape. Increased corneal aberrations caused by adverse fetal growth might be a risk factor for reduced optical image quality in later life. Background/Aims: This study investigated whether there are changes in corneal surface regularity and corneal thickness in adults born small, appropriate, or large for gestational age at term. Methods: This retrospective cohort study involved prospective Scheimpflug imaging of the cornea (Pentacam
® ) to compare the corneal thickness and aberrations between adults classified as small for gestational age (SGA), normal birth weight (BW), and large for gestational age (LGA). Multivariable linear regression was applied to analyze associations with gestational age, BW percentile, placental insufficiency, preeclampsia, and breastfeeding. Results: In total, 448 eyes of 261 individuals born full term (aged 29.9 ± 9.5 years, 140 females) were examined, including 29 severe SGA (BW < 3rd percentile), 32 moderate SGA (BW between 3rd and <10th percentile), 132 normal BW (BW between 10th and 90th percentile), 35 moderate LGA (BW between >90th and 97th percentile), and 33 severe LGA (BW > 97th percentile). There were no differences between groups in the corneal aberrations of the total cornea as well as of the corneal front surface, except for higher-order aberrations in the front of the cornea (p = 0.032). There was an association between the increased total root mean square of higher-order aberrations and lower birth weight percentile (p = 0.004), with increased higher-order aberrations correlating with lower visual acuity and spherical equivalent. Conclusion: Restricted prenatal growth is associated with increased higher-order aberrations in adulthood. [ABSTRACT FROM AUTHOR]- Published
- 2022
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9. The role of preterm birth, retinopathy of prematurity and perinatal factors on corneal aberrations in adulthood: Results from the Gutenberg prematurity eye study.
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Fieß, Achim, Berger, Lina Amalia, Riedl, Jana C., Mildenberger, Eva, Urschitz, Michael S., Hampel, Ulrike, Wasielica‐Poslednik, Joanna, Zepp, Fred, Stoffelns, Bernhard, Pfeiffer, Norbert, and Schuster, Alexander K.
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RETROLENTAL fibroplasia ,PREMATURE labor ,LOW birth weight ,CORNEA ,ADULTS - Abstract
Introduction: Prematurity and retinopathy of prematurity (ROP) are associated with altered corneal shape and reduced visual acuity in childhood, but their long‐term effects on corneal shape in later life are still unclear. This study evaluated whether prematurity and related perinatal factors are associated with corneal aberrations in adulthood. Methods: The Gutenberg Prematurity Eye Study (GPES) is a cohort study using Scheimpflug imaging of the cornea. Associations were assessed between corneal Zernike aberrations and gestational age (GA), birth weight (BW), BW percentile, ROP occurrence, ROP treatment and other perinatal factors using univariate and multivariable linear regression analyses. Results: This study involved 444 eyes of 256 individuals born preterm (aged 28.1 ± 8.4 years, 146 females) and 231 eyes of 132 individuals born full‐term (aged 29.8 ± 8.9 years, 77 females). Multivariable analyses revealed an association between corneal higher‐order aberrations and lower birth weight percentile (B = −0.001, p < 0.001) as well as ROP treatment (B = 0.120, p = 0.03). Corneal lower‐order aberrations were also associated with lower birth weight percentile (B = −0.004; p = 0.001) and ROP treatment (B = 0.838, p = 0.01) but not with ROP occurrence. Increased corneal aberrations were correlated with lower visual acuity and the spherical equivalent refractive error. Conclusions: Perinatal factors, particularly low birth weight percentile and ROP treatment lead to a more irregular corneal shape in adulthood, thereby reducing optical image quality and potentially contributing to reduced visual acuity and altered refractive error. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Refractive error, accommodation and lens opacification in adults born preterm and full‐term: Results from the Gutenberg Prematurity Eye Study (GPES).
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Fieß, Achim, Fauer, Agnes, Mildenberger, Eva, Urschitz, Michael S., Elflein, Heike M., Zepp, Fred, Stoffelns, Bernhard, Pfeiffer, Norbert, and Schuster, Alexander K.
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REFRACTIVE errors ,RETROLENTAL fibroplasia ,ANISOMETROPIA ,PREMATURE labor ,GESTATIONAL age - Abstract
Copyright of Acta Ophthalmologica (1755375X) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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11. Association of Birth Weight with Central and Peripheral Corneal Thickness in Adulthood—Results from the Population-Based German Gutenberg Health Study.
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Fieß, Achim, Urschitz, Michael S., Marx-Groß, Susanne, Nagler, Markus, Wild, Philipp S., Münzel, Thomas, Beutel, Manfred E., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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CORNEA measurement ,LOW birth weight ,EYE diseases ,EPIDEMIOLOGY ,FETAL growth retardation ,CHILD patients - Abstract
Purpose: Low birth weight (BW) is associated with altered ocular geometry such as a steeper corneal shape in adulthood. However, it is unclear whether low birth weight affects corneal thickness development in the center or periphery in adulthood which may contribute to ocular disease. The purpose of this study was to investigate corneal thickness in former low birth weight individuals in adulthood. Methods: The German Gutenberg Health Study is a prospective, population-based study in which every participant (age range 40–80 years) was measured with Scheimpflug imaging (Pentacam HR, Oculus Optikgeräte GmbH, Wetzlar, Germany). BW was collected by self-reports. The relationship between birth weight and corneal thickness at different locations were assessed. Linear regression models were carried out including uni- and multivariable analyses with adjustment for age, sex, mean corneal radius, and white-to-white distance. Main outcome measures were corneal thickness at the apex, at the pupil center, and at the corneal periphery. Results: Overall, 5657 participants were successfully measured (3019 females, aged 56.0 ± 10.3 years). In multivariable analyses a lower BW was associated with a thinner corneal thickness at the apex (B = 1.71 µm/500 g, p < 0.001) and at the pupil (B = 1.69 µm/500 g, p < 0.001). These effects diminished towards the corneal periphery resulting in no differences in the perilimbal regions. Conclusion: The present study provides evidence that lower birth weight goes along with corneal thickness alterations even into adult ages of 40 to 80 years. Thinner measurements of the cornea were particularly found in the corneal center and diminished in the periphery. This indicates that there may be fetal origins affecting corneal thickness development particularly in the corneal center. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Birth Weight and Diabetic Retinopathy: Results From the Population-Based Gutenberg Health Study (GHS).
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Fieß, Achim, Lamparter, Julia, Raum, Philipp, Peto, Tunde, Ponto, Katharina A., Nickels, Stefan, Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Urschitz, Michael S., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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DIABETIC retinopathy ,BIRTH weight ,LOGISTIC regression analysis ,GLYCOSYLATED hemoglobin - Abstract
This study investigates the relationship between diabetic retinopathy (DR) and birth weight (BW) in diabetic subjects sampled from the general population. The Gutenberg Health Study (GHS) is a population-based, observational cohort study in participants aged from 35 to 74 years. Criteria for diabetes diagnosis were HbA1c ≥6.5% at study entry, a doctor-diagnosis of diabetes, or diabetes medication. The presence of DR was determined by evaluating fundus photographs. BW was assessed by self-reports. GHS participants were divided into three different BW groups (low: <2500 g; normal: 2500–4000 g; high:>4000 g). Logistic regression analysis was conducted as uni- and multivariable analysis with adjustment for age and sex. Effect mediators were separately investigated. A total of 1,124 GHS participants (7.5% of the cohort) had diabetes at study entry. Of these, 402 subjects (35.8%) had gradable fundus photographs, reported BW data and were included into this study. Overall, 91/402 subjects (23%) had DR. With regard to BW groups, DR was descriptively more frequent in subjects with low (28.1% [95%-CI: 14.4–47.0%; n = 32]) and high BW (30.8% [95%-CI: 19.1–45.3%; n = 52]) compared to normal BW (20.8% [95%-CI: 16.5–25.7%; n = 318]). Both high and low BW were associated with DR in multivariable analysis (high: OR = 1.68, p =.037; low: OR = 1.81, p =.05). The BW effect was mediated by duration of diabetes in both BW groups and by arterial hypertension in the low BW group. Low and high BW in persons with diabetes is related to higher risk of diabetic retinopathy. Longer duration of diabetes and higher prevalence of arterial hypertension are factors in these subjects explaining the elevated risk. [ABSTRACT FROM AUTHOR]
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- 2021
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13. The relationship of ocular geometry with refractive error in normal and low birth weight adults.
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Fieß, Achim, Nickels, Stefan, Schulz, Andreas, Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Urschitz, Michael S., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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REFRACTIVE errors ,LOW birth weight ,REFRACTION (Optics) ,REGRESSION analysis ,LINEAR statistical models - Abstract
Low birth weight (BW) individuals have an increased risk for myopic refractive error. However, it is unclear which ocular geometric alterations lead to an increase in myopic refractive error. This study aims to evaluate the impact of ocular biometry in interaction with BW on refractive error. Participants of the prospective, observational, population-based Gutenberg Health Study (GHS) with self-reported BW aged 40–80 years and objective refraction and optical biometry were included. Linear regression analyses were conducted to evaluate associations between spherical equivalent with corneal power, anterior chamber depth, lens thickness and axial length and its interaction with BW adjusted for age and sex. Low BW was defined as BW<2500 g and normal BW between 2500−4000 g. Overall, 5123 participants were included. Linear regression showed an interaction of axial length (B = 0.009/100 g, p = 0.002) with BW on spherical equivalent while corneal power, anterior chamber depth and lens thickness revealed no interaction with BW on refractive error. Furthermore, linear regression analysis revealed, that axial length explains 58% of variance of spherical equivalent in low BW subjects, and 54% in normal BW subjects. In contrast, corneal power explained 1% of variance of spherical equivalent in both groups. Our results indicate that axial length variation explains the majority of variance in refractive error, while steeper corneal shape has no conclusive effects on refractive error. Low BW is not linked to effects of steeper corneal shape on myopic refractive error, while the effect of axial length on myopia is fractionally enlarged in those subjects. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Association of birth weight with corneal power in early adolescence: Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2008
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Fieß, Achim, Schuster, Alexander K., Pfeiffer, Norbert, and Nickels, Stefan
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Male ,genetic structures ,Physiology ,Vision ,610 Medizin ,Visual Acuity ,lcsh:Medicine ,Social Sciences ,Adolescents ,Cornea ,Families ,Mathematical and Statistical Techniques ,610 Medical sciences ,Medicine and Health Sciences ,Psychology ,Ethnicities ,Birth Weight ,lcsh:Science ,Child ,Children ,Age Factors ,Physiological Parameters ,Child, Preschool ,Physical Sciences ,Regression Analysis ,Sensory Perception ,Female ,Anatomy ,Infants ,Statistics (Mathematics) ,Research Article ,Adolescent ,Ocular Anatomy ,Linear Regression Analysis ,Research and Analysis Methods ,Refraction, Ocular ,Sex Factors ,Ocular System ,Humans ,Statistical Methods ,Vision, Ocular ,Nutrition ,lcsh:R ,Body Weight ,Infant, Newborn ,Biology and Life Sciences ,Astigmatism ,Infant ,Correction ,eye diseases ,United States ,Age Groups ,People and Places ,lcsh:Q ,Population Groupings ,Mathematics ,Neuroscience ,Follow-Up Studies - Abstract
PURPOSE:To analyze the effect of birth weight on ocular morphology, refraction and visual function in early adolescents aged 12-15 years. MATERIAL AND METHODS:We conducted a secondary data analysis using the public use files from the National Health and Nutrition Examination Survey of the period from 1999 to 2008. Study participants aged 12 to 15 years were included with data on birth weight and ophthalmic parameters including presenting distance visual acuity, objective refraction and keratometry. Visual acuity, sphere, astigmatism in power vectors J0 and J45, corneal power and corneal astigmatism were evaluated for an association with birth weight. Linear and logistic regression with adjustment for age, sex, ethnicity, survey cycle and birth weight as independent variable were calculated. RESULTS:Linear regression analysis revealed an association between corneal power and birth weight (per 100g: beta = -0.04, p
- Published
- 2017
15. Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years.
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Fieß, Achim, Kölb‐Keerl, Ruth, Schuster, Alexander K., Knuf, Markus, Kirchhof, Bernd, Muether, Philipp S., and Bauer, Jacqueline
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PREMATURE infants ,VISUAL acuity ,NEUROLOGY ,INFANT development ,COGNITIVE development - Abstract
Purpose: The objective of this study was to investigate the relationship between visual acuity, peripapillary retinal nerve fibre layer (pRNFL), retinal thickness at the fovea and other factors with the neurologic status of former preterm children. Methods: In this cross‐sectional hospital based study in a maximum care tertiary centre, detailed anthropometric and ophthalmological data of former preterm children ranging from 4 to 10 years of age with a gestational age (GA) ≤32 weeks were assessed. Analyses of the correlation between pRNFL and foveal thickness, as well as visual acuity (VA) parameters at 4–10 years of age, with neurological development were evaluated at 2 years of age by Bayley Scales II of Infant Development, including Psychomotor Developmental Index (PDI) and Mental Developmental Index (MDI). Results: Data were available for 106 former preterm children. Univariate analysis revealed a correlation between PDI with pRNFL thickness (B = 0.43; p = 0.013), VA (B = −29.2; p < 0.001), GA (B = 2.7; p = 0.002), retinopathy of prematurity (ROP; B = −16.3; p < 0.001) and intraventricular haemorrhages (IVH; B = −22.9; p < 0.001) but not with strabismus or foveal thickness. In the multivariable analysis, the association remained for visual acuity and IVH, but not for pRNFL thickness or ROP. Mental Developmental Index (MDI) was associated with visual acuity (B = −34.3; p = 0.001), GA (B = 2.53; p = 0.02) and IVH (B = −15.4; p = 0.02), the latter also in the multivariable analysis. Conclusion: This study revealed an association between PDI at 2 years of age and lower visual acuity later in childhood. However, there was no correlation between retinal morphology and neurologic outcome in former preterm children after adjusting for several potential confounders. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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16. Birth weight and its association with optic nerve head morphology – results from the population‐based German Gutenberg Health Study.
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Fieß, Achim, Stingl, Julia, Urschitz, Michael S., Hoffmann, Esther M., Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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OPTIC nerve ,BIRTH weight ,MORPHOLOGY ,LOW birth weight ,OPTIC disc - Published
- 2022
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17. Birthweight and its association with retinal vessel equivalents – Results from the population‐based German Gutenberg Health Study.
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Fieß, Achim, Ponto, Katharina A., Urschitz, Michael S., Nickels, Stefan, Schulz, Andreas, Münzel, Thomas, Wild, Philipp S., Beutel, Manfred E., Lackner, Karl J., Pfeiffer, Norbert, and Schuster, Alexander K.
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RETINAL blood vessels ,BIRTH weight ,LOW birth weight ,FETAL growth retardation ,BIRTH size - Published
- 2021
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