1. Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
- Author
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Kumarathasan P, Vincent R, Bielecki A, Blais E, Blank K, Das D, Karthikeyan S, Cakmak S, Fisher M, Arbuckle T, and Fraser W
- Subjects
- Adult, F2-Isoprostanes blood, Female, Gestational Age, Humans, Infant, Matrix Metalloproteinase 2 blood, Matrix Metalloproteinase 9 blood, Pregnancy, Pregnancy Outcome, Vascular Endothelial Growth Factor A blood, Biomarkers blood, Birth Weight, Oxidative Stress, Pregnancy Trimester, Third blood
- Abstract
Background: There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects., Methods and Results: Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmental Chemicals Study (MIREC) was analysed for vascular, inflammatory and oxidative stress markers by HPLC-fluorescence, protein array and EIA method. Analysis of the <25th and >75th percentile birth weight subgroups revealed markers associated with birth weight (ETs, MMP-9, VEGF, and 8-isoPGF-2α) and gestational age (ET-1, MMP-2, and VEGF)., Conclusions: Mechanistic insights into adverse birth outcome pathways can be achieved by integrating information on multiple biomarkers, physiology using systems biology approach.
- Published
- 2016
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