1. Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease During Mid-Gestation
- Author
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Varshavsky, Julia R, Robinson, Joshua F, Zhou, Yan, Puckett, Kenisha A, Kwan, Elaine, Buarpung, Sirirak, Aburajab, Rayyan, Gaw, Stephanie L, Sen, Saunak, Gao, Songmei, Smith, Sabrina Crispo, Park, June-Soo, Zakharevich, Igor, Gerona, Roy R, Fisher, Susan J, and Woodruff, Tracey J
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Pediatric ,Endocrine Disruptors ,Women's Health ,Maternal Health ,Pregnancy ,Contraception/Reproduction ,Aetiology ,2.1 Biological and endogenous factors ,Reproductive health and childbirth ,Good Health and Well Being ,Biomarkers ,Female ,Flame Retardants ,Humans ,Organophosphates ,Placenta ,Placentation ,flame retardants ,perfluoroalkyl and polyfluoralkyl substances ,biomonitoring ,developmental/reproductive health effects ,endocrine disruption ,preeclampsia ,pregnancy complications ,maternal health ,birth outcomes ,cytotrophoblast differentiation ,Pharmacology and Pharmaceutical Sciences ,Toxicology ,Pharmacology and pharmaceutical sciences - Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) and organophosphate flame retardants (OPFRs) are chemicals that may contribute to placenta-mediated complications and adverse maternal-fetal health risks. Few studies have investigated these chemicals in relation to biomarkers of effect during pregnancy. We measured 12 PFASs and four urinary OPFR metabolites in 132 healthy pregnant women during mid-gestation and examined a subset with biomarkers of placental development and disease (n = 62). Molecular biomarkers included integrin alpha-1 (ITGA1), vascular endothelial-cadherin (CDH5), and matrix metalloproteinase-1 (MMP1). Morphological endpoints included potential indicators of placental stress and the extent of cytotrophoblast (CTB)-mediated uterine artery remodeling. Serum PFASs and urinary OPFR metabolites were detected in ∼50%-100% of samples. The most prevalent PFASs were perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonic acid (PFOS), with geometric mean (GM) levels of ∼1.3-2.8 (95% confidence limits from 1.2-3.1) ng/ml compared to ≤0.5 ng/ml for other PFASs. Diphenyl phosphate (DPhP) and bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) were the most prevalent OPFR metabolites, with GMs of 2.9 (95% CI: 2.5-3.4) and 3.6 (95% CI: 2.2-3.1) ng/ml, respectively, compared to
- Published
- 2021