1. Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Author
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María Paz-Zulueta, Laura Ruiz-Azcona, Paula Parás-Bravo, Miguel Santibáñez, Ana Casteleiro, and Universidad de Cantabria
- Subjects
Cross-sectional study ,Maternal Health ,Labor and Delivery ,0302 clinical medicine ,Endocrinology ,Pre-Eclampsia ,Pregnancy ,Risk Factors ,Medicine and Health Sciences ,Childbirth ,030212 general & internal medicine ,030219 obstetrics & reproductive medicine ,Multidisciplinary ,Obstetrics ,Obstetrics and Gynecology ,Gestational diabetes ,Obstetric Procedures ,Medicine ,Female ,Research Article ,Maternal Age ,Adult ,medicine.medical_specialty ,Endocrine Disorders ,Science ,Surgical and Invasive Medical Procedures ,03 medical and health sciences ,Statistical significance ,medicine ,Diabetes Mellitus ,Humans ,Advanced maternal age ,Gestational Diabetes ,business.industry ,Cesarean Section ,Infant, Newborn ,Biology and Life Sciences ,Neonates ,Odds ratio ,medicine.disease ,Preeclampsia ,Delivery, Obstetric ,Confidence interval ,Health Care ,Pregnancy Complications ,Diabetes, Gestational ,Cross-Sectional Studies ,Spain ,Metabolic Disorders ,Birth ,Women's Health ,Health Statistics ,Morbidity ,business ,Developmental Biology - Abstract
Background and objective: Over recent decades, a progressive increase in the maternal age at childbirth has been observed in developed countries, posing a health risk for both women and infants. The aim of this study was to analyze the association between advanced maternal age (AMA) and maternal and neonatal morbidity. Material and methods: A cross-sectional study of 3,315 births was conducted in the north of Spain in 2014. We compared childbirth between women aged 35 years or older, with a reference group of women aged between 24 and 27 years. AMA was categorized based on ordinal ranking into 35-38 years, 39-42 years, and >42 years to estimate a dose-response pattern (the older the age, the greater the risk). As an association measure, crude and adjusted Odds Ratios (OR) were estimated by non-conditional logistic regression and 95% Confidence Intervals (95%CI) were calculated. Results: Repeated abortions were more common among women of AMA in comparison to pregnant women aged 24-27 years (reference group): adjusted OR = 2.68; 95%CI (1.52-4.73). A higher prevalence of gestational diabetes was also observed among women of AMA, reaching statistical significance when restricted to first time mothers: adjusted OR = 8.55; 95%CI (1.12-65.43). In addition, the possibility of an instrumental delivery was multiplied by 1.6 and the possibility of a cesarean by 1.5 among women of AMA, with these results reaching statistical significance, and observing a dose-response pattern. Lastly, there were associations between preeclampsia, preterm birth (
- Published
- 2019