1. Lymphocyte Phospho-Ser-9-GSK-3β/Total GSK-3β Protein Levels Ratio Is Not Affected by Chronic Lithium or Valproate Treatment in Euthymic Patients With Bipolar Disorder.
- Author
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Azab AN, Vainer E, Agam G, and Bersudsky Y
- Subjects
- Adult, Antimanic Agents administration & dosage, Female, Humans, Lithium Compounds administration & dosage, Lymphocytes enzymology, Male, Middle Aged, Valproic Acid administration & dosage, Antimanic Agents pharmacology, Bipolar Disorder drug therapy, Glycogen Synthase Kinase 3 beta drug effects, Lithium Compounds pharmacology, Lymphocytes drug effects, Valproic Acid pharmacology
- Abstract
Background: Glycogen synthase kinase-3 (GSK-3) inhibition by lithium has been well established in vitro, but proof that this biochemical effect mediates lithium's beneficial action in patients with bipolar disorder is lacking. We studied whether lymphocyte GSK-3β activity measured indirectly in lithium- or valproate (VPA)-treated euthymic patients with bipolar disorder is different from controls., Methods: Lymphocyte total and Ser-9-phospho-GSK-3β (inactive) levels were measured by Western blotting. Forty-seven patients with bipolar disorder and 32 age- and sex-matched control subjects were studied., Results: No significant differences were found between lithium- and VPA-treated patients and controls in phospho-GSK-3β, total GSK-3β, or their ratio., Conclusions: The data do not support the concept that in vivo, during chronic treatment of bipolar illness, GSK-3β is inhibited either by lithium or by VPA.
- Published
- 2017
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