1. Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study
- Author
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María Angeles Vaz Salgado, Julie Earl, Victor Rodriguez Berrocal, Freddy Salge Arrieta, Ana Gomez, Juan Manuel Sepulveda-Sanchez, Ángel Perez-Nuñez, Elena Corral de la Fuente, Daniel Lourido, null MaríaVillamayor, Hector Pian, Alfonso Muriel, Elisabetta Rossi, Rita Zamarchi, Alfredo Carrato, and Luis Ley
- Subjects
Biotechnology - Abstract
Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: 40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.
- Published
- 2022