1. Paeoniflorin, a monoterpene glycoside, attenuates lipopolysaccharide-induced neuronal injury and brain microglial inflammatory response
- Author
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Dong-Hyung Cho, Joon H. Lee, Kyong Nyon Nam, Che Gyem Yae, Eun Joo Lee, and Joung-Woo Hong
- Subjects
Bridged-Ring Compounds ,Lipopolysaccharides ,Lipopolysaccharide ,Interleukin-1beta ,Anti-Inflammatory Agents ,Bioengineering ,Pharmacology ,Nitric Oxide ,Benzoates ,Hippocampus ,Applied Microbiology and Biotechnology ,Neuroprotection ,Proinflammatory cytokine ,chemistry.chemical_compound ,Glucosides ,medicine ,Animals ,Immunologic Factors ,Inflammation ,Cell Death ,Microglia ,Tumor Necrosis Factor-alpha ,Neurotoxicity ,Brain ,Interleukin ,General Medicine ,Paeoniflorin ,medicine.disease ,Rats ,Neuroprotective Agents ,medicine.anatomical_structure ,chemistry ,Immunology ,Monoterpenes ,Tumor necrosis factor alpha ,Biotechnology - Abstract
Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Paeoniflorin (PF), a water-soluble monoterpene glycoside found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, such as anti-oxidant, anti-inflammatory, and anti-cancer effects. Neuroprotective potential of PF has also been demonstrated in animal models of neuropathologies. Here, we have examined the efficacy of PF in the repression of inflammation-induced neurotoxicity and microglial inflammatory response. In organotypic hippocampal slice cultures, PF significantly blocked lipopolysaccharide (LPS)-induced hippocampal cell death and productions of nitric oxide (NO) and interleukin (IL)-1β. PF also inhibited the LPS-stimulated productions of NO, tumor necrosis factor-α, and IL-1β from primary microglial cells. These results suggest that PF possesses neuroprotective activity by reducing the production of proinflammatory factors from activated microglial cells.
- Published
- 2013