Search

This paper analyses evidence of innovation in the joint work of a company, a university and government in creating a professional Master's degree program in Biotechnology and Innovation Management at the Centro Universitário de Sete Lagoas, Minas Gerais, Brazil. It presents a new perspective by combining two fields of knowledge: biotechnology and innovation management. The conceptual scheme of Triple Helix spaces is still not well analyzed from an empirical viewpoint. This paper identifies the development of knowledge, consensus and innovation spaces through an examination of this professional Master's course. A qualitative approach was used for the conducting of 20 semi-structured interviews with representatives of the Triple Helix: two directors of Embrapa, a Brazilian agriculture and livestock research company; the President of FAPEMIG, the Minas Gerais Research Support Foundation; nine teachers; and eight students. In addition, data were analyzed from the databases of CAPES (Coordination for the Improvement of Higher Education Personnel). The results show that the proximity between the knowledge areas of biotechnology and innovation management strengthened this new program, created only 7 years ago, which has already impacted socio-economic regional development.

This paper analyzes the role of the university research laboratory in university-industry interactions for technology transfer. Specifically, it examines how the laboratory research infrastructure, team qualification and local incentives influence knowledge and technology transfer in biotechnology. Despite the importance of the research laboratory for an entrepreneurial university and the development of new technologies, few studies have focused on this level of analysis. This research addresses this literature gap with data from two leading laboratories in a highly-ranked Brazilian university. Data were collected through questionnaires on laboratory infrastructure and channels of collaboration with firms, interviews with laboratory leaders and key post-doc fellows, and documentary research. The results show that physical infrastructure, biological samples and qualified teams enabled technology transfer to firms. The main channel of interaction between these laboratories and firms is the generation of spin-offs, which perform the bilateral hybrid function of disseminating university research results and brokering patent licensing to larger firms. Spin-offs also contribute to the absorptive capacity of larger firms and, above all, allow laboratories to disclose results to the community and potential end-users. The findings present a new perspective on spin-off technology transfer in Brazil and open new research avenues for other developing countries.

Taking into account that the industrial processing of passion fruit generates significant amounts of waste (only the peels represent 51% of the total mass of the fruit), in the present study an economic analysis was conducted to evaluate industrial line viability for pectin extraction from passion fruit peels. Knowing that absolute ethanol (99.50% purity), used in the precipitation and washing steps, has a higher cost, a simulation of extractive distillation was performed using solvents ethylene glycol and glycerol, in the software Aspen Plus v.11, being possible to recover 99.63% of ethanol for both solvents. The results of the economic evaluation showed that the process using ethylene glycol has an advantage, mainly due to its higher profitability (1.13 times higher), lower production cost (94.86% of the price using glycerol), and a lower breakeven point (around 3% smaller). The financial indicators showed profitability and attractiveness for the implementation of this processing line.

There are two principal types of nickel (Ni) deposits: sulfide and laterite ores. Interest in low-grade Ni-laterite ores has increased in recent years as high-grade Ni-sulfide deposits are being quickly depleted. However, processing of Ni laterites has proven technically difficult and costly, and the development of alternative low-cost biotechnologies for Ni solubilization has been encouraged. In this context, by the first time, a sample of Brazilian Ni-laterite ore was analyzed mineralogically and subjected to bioleaching tests using a heterotrophic Bacillus subtilis strain. SEM-analysis indicated that the primary Ni carrier mineral is goethite. Chemical analysis of different grain size fractions indicated a homogeneous distribution of Ni. XRF-analysis showed that the ore consists mainly in lizardite (32.6% MgO) and contains1.0% NiO (0.85% Ni). Bioleaching batch experiments demonstrated that about 8.1% Ni (0.7 mg Ni/g ore) were solubilized by the B. subtilis after 7 days. Application of microwave heating as a Ni-laterite pretreatment was also tested. This pretreatment increased the bioextraction of Ni from 8% to 26% (2.3 mg Ni g -1 ore)., (© 2019 American Institute of Chemical Engineers.)

This short commentary discusses the continuing role of war and militarism in the development of biotechnologies. I follow current and past events in the US related to the establishment of a formal structure - an intelligence community-led advanced research projects agency - where the military can interact with the market and act as an incubator and a consumer of new (bio)technologies. I contrast this traditional united-statian approach with the current way the Brazilian Science, Technology and Innovation System is organized. The paper discusses the implications of these fundamentally different ways of producing (bio)technologies. [ABSTRACT FROM AUTHOR]

Background: Immersive virtual reality (VR) is increasingly used in organizational training interventions. However, few studies have systematically investigated VR compared to standard training methods in actual organizational contexts. Objectives: The focus of this study was to evaluate the effectiveness of a VR simulation for training professionals in the biotech industry. Aligning training needs to unique media affordances, the study designed an immersive story‐based VR simulation for training customer‐facing employees on a new product and tested it in an international biotech company. Methods: The system was evaluated by comparing its effectiveness to a traditional video presentation with the same content in a randomized between subjects experiment. The sample consisted of 95 employees across three locations: Brazil, Denmark, and USA. Results: The VR simulation group performed better than the video presentation group on the outcomes of conceptual knowledge (d = 0.41) spatial knowledge (d = 0.61), transfer intentions (d = 0.57), enjoyment (d = 1.74), self‐efficacy (d = 0.68), perceived learning (d = 0.89), personal value (d = 0.83), and organizational value (d = 0.82), but no significant difference was found for factual knowledge (d = −0.10). Implications: Results suggest that VR simulations can be effective across cultures in organizational training interventions. VR is specifically effective when the goals of the training are to increase conceptual and spatial understanding as well as enjoyment, and self‐efficacy, but not factual knowledge. Furthermore, employees report higher levels of perceived learning, personal and organizational value and transfer intentions after VR training compared to standard video‐based training. Lay Description: What is currently known about the subject matter: Immersive virtual reality (VR) is increasingly used in organizational training interventions. This interest has especially surged amid recent global challenges, and the sudden need for companies and employees to adapt to the new remote working conditions.However, few studies have systematically investigated VR compared to standard training methods in actual organizational contexts that include a real‐world scenario and a representative testing sample.Applied research that assesses the outcomes of VR based training in realistic learning and training settings is needed. What their paper adds: We propose and test an interdisciplinary approach that links unique features of VR with training needs and multidimensional outcome measures in an organizational training context within the biotech industry in Brazil, Denmark and USA.The findings suggest that a specifically designed VR tool is superior to a comparable video presentation for the outcomes of spatial and conceptual knowledge acquisition and transfer intentions, but not factual knowledge acquisition.The VR group also reported significantly higher personal value, organizational value, self‐efficacy, perceived learning, and enjoyment compared to the video group. Implications of study findings for practitioners: The results support the value of using VR simulations in organizational training, specifically related to affective outcomes as well as spatial and conceptual knowledge and transfer intentions.The study suggests that it is not the medium of VR, but rather the alignment between the training goals with the instructional methods and the unique affordances of VR that will contribute to better or worse learning outcomes.The article describes how to evaluate the effectiveness of VR tools in applied contexts, suggesting that we have to evaluate the effectiveness of tested content with respect to different outcome variables, which coincide with the training outcomes of a particular organizational context.The project as a whole, can be used as a blueprint for future applied research efforts, exemplifying how to bridge gaps between small‐medium‐enterprises, international corporate companies and academic institutions. [ABSTRACT FROM AUTHOR]

Summary: Rivulidae comprises a family of fish largely distributed in Brazil that includes 201 species, of which 125 are considered endangered. This fact emphasizes the need for development of conservation strategies including studies on genetics and reproduction. In this paper, we describe aspects of biology and reproduction of the rivuliid species Hypsolebias sertanejo. We outline the reproductive behaviour of this species under laboratory conditions, analyze ploidy status by flow cytometry, describe reproductive behaviour and performance and test dry and wet incubation of eggs. Although H. sertanejo showed well known patterns of reproductive behaviour, we verified many peculiarities inherent to its reproductive biology. As expected, most individuals were diploid (87.71%), however 14.29% were considered mosaics. Although no sterility was observed within mosaics, infertility of these fish was not fully evaluated. Hatching rate of the eggs collected was very low following both dry and wet incubation (5.04 and 3.79%, respectively). These results provide interesting information regarding the reproductive success of this species, and suggest that chromosomal abnormalities described may reduce the survival of H. sertanejo under natural conditions, limiting the perpetuation of this species, and emphasizing the need for more preservation efforts, including artificial propagation and gene banking. [ABSTRACT FROM AUTHOR]

This article discusses the scientific production carried out by the largest bioenergy research program in Brazil, the São Paulo Research Foundation Bioenergy Research Program (BIOEN‐FAPESP), in the period from 2008 to 2019. The study draws on a list of BIOEN publications on the Web of Science (WoS) platform, containing over 1000 articles, grouped under ResearcherID H‐6149‐2012. The methods applied in the study were based on the information specific to each article and involved the construction of networks including authors, countries, research subjects, and direct citations. Communities were built based on network properties and their content was extracted from articles abstracts, titles and keywords, using text mining techniques. We also obtained quantitative measures for BIOEN scientific output. The analysis found that BIOEN produced relevant knowledge, and contributed to the emergence of new research areas in the bioenergy sector. Overall, BIOEN was decisive for the advancement of bioenergy research in Brazil, and resulted in the expansion of the knowledge base for ethanol production. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Several economies around the world are using second-generation (2G) ethanol produced from agricultural residues, like sugarcane straw and bagasse, as a sustainable solution to replace petroleum products. Since first-generation (1G) ethanol uses the sugars of sugarcane, an integrated 1G⁻2G production would enable the production of more ethanol from the same amount of sugarcane without leading to increased use of arable land. The ethanol production process is complex, involving different high-energy consumption operations such as evaporation and distillation. The economic competitiveness of this process depends heavily on the amount of thermal and electrical energy produced using sugarcane straw and bagasse as input. Thus, the objective of this study was to use the mean-variance methodology to determine the optimal allocation of residual sugarcane biomass between 2G ethanol and bioelectricity productions, with simultaneous objectives of maximizing the return and minimizing the risk for investors of this sector. In this paper, four scenarios are analyzed. The first one is the base scenario that represents the current state of production costs and investments. scenarios 2, 3, and 4 considered four cuts of 10%, 20%, and 40% in the production cost of ethanol 2G, respectively. The results show the optimum biomass allocations and the growth rates of returns as a function of risk growth. It can be concluded that from scenario 4, the production of 2G ethanol becomes financially advantageous for the investor, presenting greater returns with smaller risks.

Following an 8-year-long dispute over cotton subsidies, Brazil and the US signed a Memorandum of Understanding on 21 April 2010, effectively paving the way for settling the dispute. This paper argues that cotton subsidies are just the tip of the iceberg while a number of other, perhaps more important, issues require attention and, indeed, political will. Chief among them is the persistent divergence between cotton prices and the prices of other agricultural commodities which reflects, for the most part, the large supply response by China and India, a direct consequence of conversion to biotech cotton varieties in these (and other) countries. Such a response - which kept cotton prices low, compared to other commodities - imposes a competitive disadvantage to nonusers of biotech cotton. The paper also highlights two additional constraints faced by the cotton-producing countries of West and Central Africa, namely the structural inefficiencies of their primary processing industries (also known as ginning) and the appreciation of the CFAf against the US dollar. Without downplaying the importance of subsidy elimination, this paper concludes that these impediments should receive high priority in the policy agenda. [ABSTRACT FROM AUTHOR]

This paper explores the national and transnational character of mobilization against GM crops in India, South Africa and Brazil in the ten-year period to 2005. By examining the contexts and practices of mobilization across the three countries, and in particular the complex, often fraught, local and global connections, the paper examines the diverse mobilizations that have occurred. The paper argues that to understand these processes, particular national political and economic contexts must be appreciated, alongside how the GM debates articulate with other foci for activism and the complex and often fragile nature of alliances that make up activist networks. The paper shows how the debate about GM crops has become a much wider one: about the future of agriculture and small-scale farmers, about corporate control and property rights and about the rules of global trade. In sum, a debate not just about the pros and cons of a particular set of technologies, but about politics and values and the future of agrarian society. [ABSTRACT FROM AUTHOR]

Copyright of Revista Geociências is the property of Revista Geociencias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study proposes an innovation, which is to use a non-circular and bio-inspired forced conduit (a new penstock with a cross section inspired by a tree trunk), to control the effects of hydraulic transients in Brazilian small hydropower plants (SHPs). The aim is to demonstrate that natural structures, adapted to periodic environmental disturbances, are better at hydraulic transient control than traditional conduits. The proposed methodology includes the following steps: (1) problem identification; (2) potential biological model identification; (3) development of alternatives; (4) implementation and testing; and (5) solution selection. This research was conducted at the São Tadeu I SHP, in the city of Santo Antônio de Leverger/MT, Brazil. The following tree biological models from the Brazilian savannah (Cerrado) were used: Handroanthus capitatus and Strychnos pseudoquina. The proposed innovation improves the conduit of the traditional circular section and the relief valve solution of the criteria studied. The reason for this improvement was the reduction of wave speed in the non-circular section (from 1126 to 583 m s−1). [ABSTRACT FROM AUTHOR]

Biopharmaceutical innovation has had a profound health and economic impact globally. Developed countries have traditionally been the source of most innovations as well as the destination for the resulting economic and health benefits. As a result, most prior research on this sector has focused on developed countries. This paper seeks to fill the gap in research on emerging markets by analyzing factors that influence innovative activity in the indigenous biopharmaceutical sectors of China, India, Brazil, and South Africa. Using qualitative research methodologies, this paper a) shows how biopharmaceutical innovation is taking place within the entrepreneurial sectors of these emerging markets, b) identifies common challenges that indigenous entrepreneurs face, c) highlights the key role played by the state, and d) reveals that the transition to innovation by companies in the emerging markets is characterized by increased global integration. It suggests that biopharmaceutical innovators in emerging markets are capitalizing on opportunities to participate in the drug development value chain and thus developing capabilities and relationships for competing globally both with and against established companies headquartered in developed countries. [ABSTRACT FROM AUTHOR]

This paper examines the extent to which government initiatives in Brazil have been successful in promoting innovative activities in biotechnology both in academia and industry, and also in setting the foundation for the development of the Brazilian Biotechnology Innovation Network (BBINet). The federal government's role in carrying out these tasks is, however, shown to have been somewhat ambivalent. On the one hand, the government appears to have been reluctant and even wanting in its pursuit of science and technology policy. This is mainly reflected in the instability of government funding for innovation, which is claimed to have contributed to the weakness of the innovation network. In addition, policy has not been operating as a system geared to maximizing the benefits of synergy and the release of Brazil's innovative potential. On the other hand, government policies have been crucial for the emergence and growth of the BBINet. The existence of some programmes and some 'islands of efficiency' show that it is possible to establish efficient networks of innovation. Given this evident potential and recent changes in the perception of Brazil's innovation potential in government and academic circles, there are grounds for hope. Realization of this hope is, however, contingent upon the provision of policy stability in lieu of the institutional 'roller-coaster' that has been at the heart of Brazil's science policy. It would also depend on the extent of the scope for exploiting synergies between different policy domains that affect innovation. [ABSTRACT FROM AUTHOR]

Malaria continues to be a serious global public health problem in subtropical and tropical countries of the world. The main drugs used in the treatment of human malaria, quinine and artemisinin, are isolates of medicinal plants, making the use of plants a widespread practice in countries where malaria is endemic. Over the years, due to the increased resistance of the parasite to chloroquine and artemisinin in certain regions, new strategies for combating malaria have been employed, including research with medicinal plants. This review focuses on the scientific production regarding medicinal plants from Brazil whose antimalarial activity was evaluated during the period from 2011 to 2022. For this review, four electronic databases were selected for research: Pubmed, ScienceDirect, Scielo and Periódicos CAPES. Searches were made for full texts published in the form of scientific articles written in Portuguese or English and in a digital format. In addition, prospects for new treatments as well as future research that encourages the search for natural products and antimalarial derivatives are also presented. A total of 61 publications were encountered, which cited 36 botanical families and 92 species using different Plasmodium strains in in vitro and in vivo assays. The botanical families with the most expressive number of species found were Rubiaceae, Apocynaceae, Fabaceae and Asteraceae (14, 14, 9 and 6 species, respectively), and the most frequently cited species were of the genera Psychotria L. (8) and Aspidosperma Mart. (12), which belong to the families Rubiaceae and Apocynaceae. Altogether, 75 compounds were identified or isolated from 28 different species, 31 of which are alkaloids. In addition, the extracts of the analyzed species, including the isolated compounds, showed a significant reduction of parasitemia in P. falciparum and P. berghei , especially in the clones W2 CQ-R (in vitro) and ANKA (in vivo), respectively. The Brazilian regions with the highest number of species analyzed were those of the north, especially the states of Pará and Amazonas, and the southeast, especially the state of Minas Gerais. Although many plant species with antimalarial potential have been identified in Brazil, studies of new antimalarial molecules are slow and have not evolved to the production of a phytotherapeutic medicine. Given this, investigations of plants of traditional use and biotechnological approaches are necessary for the discovery of natural antimalarial products that contribute to the treatment of the disease in the country and in other endemic regions. [Display omitted] • Malaria continues to be a serious global public health problem. • Malaria is endemic in the Amazon and, in Brazil, 99.9% of notifications of cases and deaths from malaria occur in this region. • A total of 61 papers on Brazilian plants with antimalarial activity were published from 2011 to 2022. • 75 compounds were identified or isolated from 23 different species, 31 of which are alkaloids. [ABSTRACT FROM AUTHOR]

Germination is a simple and cost-effective technology that enhances the technological, sensory, and nutritional potential of grains, making them more attractive for use in the food industry. Germinating indigenous seeds is an alternative to increase noticeability and add value to these grains, which hold social and economic significance in the regions where they are cultivated, such as creole purple pericarp corn (PPCC) from the Couto Magalhães de Minas region in Brazil. This study aimed to optimize the germination parameters of time (24–96 h) and temperature (18–32 °C) for PPCC to produce water-soluble extracts and bread. Endogenous enzymes resulting from the germination process significantly enhanced (p < 0.10) the technological (total reducing sugars, total soluble solids, and soluble proteins) and biological properties (γ-aminobutyric acid, total soluble phenolic compounds, and antioxidant capacity) of the water-soluble extracts. The optimum point for obtaining the extracts was found to be at 85.3 h at 30.46 °C (with desirability of 90.42%), and this was statistically validated. The incorporation of germinated PPCC flours into bread was also promising (p < 0.10) and had a positive impact on the dough property (dough volume increase) and the final product, especially in terms of instrumental texture (springiness, cohesiveness, gumminess, chewiness, and resilience), resulting in a softer texture (lower firmness and hardness). The addition of PPCC flours did not alter instrumental color parameters, which may lead to greater consumer acceptance due to imperceptible differences in color to untrained individuals, with the optimized point at 96 h at 29.34 °C, with a desirability of 92.60%. Therefore, germinated PPCC shows promise for use as a base for obtaining water-soluble extracts and in bread as a replacement for commercial flour improvers, while also adding value to a raw material that is part of the local culture and agrobiodiversity. [ABSTRACT FROM AUTHOR]

The analysis of patent activity is one methodology used for technological monitoring. In this paper, the activity of biotechnology-related patents in Brazil were analyzed through 30 International Patent Classification (IPC) codes published by the Organization for Economic Cooperation and Development (OECD). We developed a program to analyse the dynamics of the major patent applicants, countries and IPC codes extracted from the Brazilian Patent Office (INPI) database. We also identified Brazilian patent applicants who tried to expand protection abroad via the Patent Cooperation Treaty (PCT). We had access to all patents published online at the INPI from 1975 to July 2010, including 9,791 biotechnology patent applications in Brazil, and 163 PCTs published online at World Intellectual Property Organization (WIPO) from 1997 to December 2010. To our knowledge, there are no other online reports of biotechnology patents previous to the years analyzed here. Most of the biotechnology patents filed in the INPI (10.9%) concerned measuring or testing processes involving nucleic acids. The second and third places belonged to patents involving agro-technologies (recombinant DNA technology for plant cells and new flowering plants, i.e. angiosperms, or processes for obtaining them, and reproduction of flowering plants by tissue culture techniques). The majority of patents (87.2%) were filed by nonresidents, with USA being responsible for 51.7% of all biotechnology patents deposited in Brazil. Analyzing the resident applicants per region, we found a hub in the southeast region of Brazil. Among the resident applicants for biotechnology patents filed in the INPI, 43.5% were from São Paulo, 18.3% were from Rio de Janeiro, and 9.7% were from Minas Gerais. Pfizer, Novartis, and Sanofi were the largest applicants in Brazil, with 339, 288, and 245 biotechnology patents filed, respectively. For residents, the largest applicant was the governmental institution FIOCRUZ (Oswaldo Cruz Foundation), which filed 69 biotechnology patents within the period analyzed. The first biotechnology patent applications via PCT were submitted by Brazilians in 1997, with 3 from UFMG (university), 2 from individuals, and 1 from EMBRAPA (research institute).

This paper analyzes the regulation of genetically modified organisms ( GMOs) in Brazil, focusing on the debates that preceded the enactment in 2005 of the current Biosafety Law and the factors (both domestic and international) that influenced the policy-making process. More specifically, it identifies the social and governmental actors that influenced the congressional debates, showing how their interests and agenda were translated into two different institutional frameworks. Here, the policy outcome was what we call a 'hybrid' and 'conciliatory' regulatory model, which formally acknowledges the importance of both technical/scientific and social/political considerations in the evaluation of GMO biosafety and engages most of the stakeholders in the regulatory process. The new policy regime also establishes a middle ground between the conflicting demands of promoting agricultural development and protecting the country's biodiversity. [ABSTRACT FROM AUTHOR]

The aim of this paper is to demonstrate the synergy between Competitive Intelligence, Knowledge Management and Technological Foresight, and to emphasize the proposal of a strategic model of data prospecting as a mechanism to support decision-making in regard to three approaches for sustainable development and innovation: technological, social and economic. The use of biotechnology in the development of drugs against breast cancer is the case study. The article shows the results of data and text mining in specialized medical and patent databases, identifying the most frequently cited drugs, as well as the authors of research, and the inventors of new technology at the beginning of the 21st century. In addition, the study includes reference to Brazilian competence in breast cancer area, the international trends in drugs for treatment of this cancer, leading international institutions and Brazilian competencies. A framework is presented, which could serve as a guide and support for the decision-making process.

The strategy described in the present paper offers details about the possibility for Brazil to play a more substantial role in the gene revolution. If successfully applied, the powerful science-based technology currently available in Brazil can contribute to extend the benefits of the gene revolution to the poorest countries, very much like the Green Revolution did in the past, thereby reducing the hunger syndrome which claimed the lives of millions of people in some Asian countries, particularly Pakistan and India, decades ago. In his visit to Brazil in February 2004, Norman Borlaug had the opportunity to witness the success of Brazilian agriculture. At a Conference held at ESALQ - Superior School of Agriculture Luiz de Queiroz in Piracicaba, SP, Brazil, he stated that the 21st century revolution will come from Brazil in the area of agriculture. He also said that reducing hunger is essential for the world to achieve socioeconomic stability. A central question remains unanswered: who will fund this revolution? The FAO 2003-2004 Annual Report listed the barriers preventing the gene revolution from reaching the poorest countries: inadequate regulatory procedures-Intellectual Property Rights and Biosafety, poorly functioning seed delivering systems and weak domestic plant breeding capacity; all are discussed in this paper.

Copyright of Revista Iberoamericana de Ciencia, Tecnologia y Sociedad is the property of Centro de Estudios sobre Ciencia, Desarrollo y Educacion Superior and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper argues that less developed countries (LDCs) need twin national systems of innovation: systems with one, 'upper' level or sub-system to engage with advanced technology and develop industries which use it; and (cooperating with the upper level) a 'lower' level to help to improve the economy's existing, traditional technology. The focus is on the lower level. The process there should involve the development and use of intermediate technologies. These are much better suited to the LDC's factor endowment, and maximise the opportunities for learning by doing. Most LDCs lack such a lower level, and lose much from this; Brazil is an example. Japan and Taiwan developed twin NSIs and gained accordingly, until success caused the levels to merge. 19th century Denmark and Malaysia recently are other cases in point. Mainland China failed to build on its 1950s beginnings and the lower level of its NSI is now weak. The lower level of the NSI needs to be closely coupled with the upper level of the NSI, as the Japanese example shows. Key modern technologies, such as (nowadays) ICT and biotechnology, can only be made available to the lower level of the NSI through the upper level of the NSI. In biotechnology, for example, one role of the upper level of the NSI would be to conduct genetic modification of crop plants, e.g. insect-resistant cotton - as it has been doing vigorously in China. The corresponding role of the lower level of the NSI would be to cross-breed GM crops with local varieties adapted in each area to the local soil and climate. In ICT, where the Chinese effort at upper NSI level has been massive, the lower level of the NSI needs from the upper level a tool kit of simple, robust, cheap hardware and (open source) software: with this, local agricultural cooperatives and rural producers of manufactures could, for example, develop their own websites, and their own computer-controlled equipment. [ABSTRACT FROM AUTHOR]

Abstract: Brazil''s research and development (R&D) policies are examined in light of changes in economic direction especially as it pertains to competition. In a competitive environment, regions should develop industrial applications and expertise in areas that coincide with their resources. These could be human resources but could, as in the focus of this paper, be useful resources that differentiate the region from others in the world. This differentiation provides an advantage to the region. Brazil and its Amazon region has the large majority of the world''s rare genes. In biotechnology, genes are ¿green gold,¿ and Brazil is slowly developing a biotechnology industry and beginning to tap into the Brazilian Amazon region''s economic biotech potential. This region has enormous potential for the development of biotech-related technologies and products. This paper discusses the relationship between resources and an R&D strategy using as an example the recent developments in biotechnology research in Brazil and the role of the Amazon region in the development of a Brazilian biotechnology industry. It recommends a number of policy initiatives that will enhance Brazil''s focus on biotechnology. [Copyright &y& Elsevier]

Monsanto’s request to commercialize its genetically-modified (GM) herbicide-resistant soybean technology in Brazil sparked heated debate and protest. This paper explores the conflict and illustrates how biosafety politics and policy outcomes are highly contested and situated, rather than controlled by external forces within the ever-expanding global economy. This paper argues that GM crops are not inherently artifacts of economic globalization and trade liberalization. What makes GM crops ‘global’ and part of a new iterative and uneven globalization process are the new and unanticipated sites of contradiction and contestation and the multi-scaled conflict over biotechnology governance. Political strategies taken by the state government in Rio Grande do Sul, Brazilian consumer protection activists, and Greenpeace exploit the new ‘nature’ of GM crops as a means to expand the debate, change the rules governing the genetic commons, and consequently, rescale biotechnology governance. [Copyright &y& Elsevier]

In 1983 a new funding program--PADCT ("Programa de Apoio ao Desenvolvimento Cientifico e Tecnológico")--was created in Brazil to stimulate the development of research projects related to what was established as technological priorities. In this paper 3 features of the Biotechnology/Health subprogram of PADCT were studied: a) to what extent productivity of the leaders of the research projects affected the way they were evaluated by the award panel, b) the conflict of interests that might result from the composition of the award panel, and c) the final impact of the program on science and technology. In our sample of 210 submitted projects, 62 were funded. The data suggest that the selection of projects did not ensure a better funding for the more productive research leaders. The presence on the award panel of at least one member from the same institution of a given project increased the chance of its approval but, after approval, it had no influence on the amount of funds granted. In a subsample of 21 scientists, support to 24 projects did not increase the productivity level and 4 products in a preliminary phase of development were reported. The issue of trying to solve problems in areas where there is no established scientific competence is discussed.

Despite the significant advances of Brazilian agriculture, transportation and storage costs still constitute the main barriers to the Brazilian agribusiness. The aim of this article is to analyze the effect of segregation of maize and soybeans in the Brazilian transport and storage logistics, especially genetically modified grains. In the context of the guidelines of the Cartagena Protocol on Biosafety (CPB) as well as of the competitiveness in the international market, we develop a spatial equilibrium model in the form of a mixed complementarity problem. The competitiveness of Brazilian maize and soybeans on the international market is compromised by the inefficient logistics and slow responses to the demands of the CPB. The contribution of the paper is to evaluate how regulatory issues of a segment, in this case biotechnology, may interfere with logistic infrastructure projects. [ABSTRACT FROM AUTHOR]

Copyright of Revista de Ciencias Agroveterinarias is the property of Revista de Ciencias Agroveterinarias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tapuya: Latin American Science, Technology & Society is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: The bioeconomy is a strategic program strongly promoted within OECD countries. This paper discusses an example of how the purposes and promises of the bioeconomy are enacted in Brazil, in line with local environmental and political specificities. We focus on scientific and political discourse portraying a technological solution to tackle dengue disease as a public health problem. The technology involves genetically modified mosquitoes that are released into the environment in order to suppress populations of disease-carrying mosquitoes. We show how the promise of tackling dengue, through technical and scientific arguments, becomes connected to political discourse about the welfare and ‘progress’ of Brazil as a nation. We argue that this connection comes about through two types of rhetoric devices that downplay risk and uncertainties in favor of the promises inscribed in laboratory-bred mosquitoes. In line with a basic tenet in the field of Science and Technology Studies, it becomes clear that science and politics are intertwined in both discourse and practice. In addition, we highlight the experimental and political character of public health interventions from a spatial perspective. The mosquitoes are set free in an environment that is considered a natural environment while at the same time responding to certain laboratory conditions such as relative isolation. In addition, the genetically modified mosquitoes, as bio-objects, are expected to act like natural mosquitoes in the wild. With these types of proximity between technology and nature in mind, we argue that the mosquitoes are meant not only to enact the pest management program they have been designed for, but also a political program claiming an avant-garde position of Brazil in a global bioeconomy. [Copyright &y& Elsevier]

Copyright of Brazilian Review of Economics & Agribusiness / Revista de Economia e Agronegócio is the property of Brazilian Review of Economics & Agribusiness / Revista de Economia e Agronegocio and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Male piglets are commonly castrated to eliminate the risk of boar taint. Surgical castration is the commonly used procedure and is known to induce pain. Gene modification targeted at eliminating boar taint in male pigs has been proposed as a possible alternative to surgical castration. The aims of this study were to explore public acceptability of this biotechnology using a mixed methods approach. Quantitative data to assess acceptability of 570 participants from southern Brazil were analysed with multinomial logistic regression models and Spearman correlations; qualitative responses of the reasons provided in support of their position were coded into themes. Just over half of the participants (56%) considered gene modification of male pigs acceptable. Acceptability was lower among participants who grew up in an agricultural environment (ρ = 0.02), but was not influenced by sex, age, religion, urban or rural living, or level of education. Acceptability of gene modification of male pigs as an alternative to surgical castration was positively related to the perception of benefits (r = -0.56, ρ<0.0001) and negatively related to the participant’s perception of risks (r = -0.35, ρ<0.0001). Acceptability was not related to knowledge of basic concepts of genetic biotechnologies (r = 0.06, ρ<0.14), or to awareness of issues related to pig castration or boar taint (r = 0.03, ρ<0.44), both of which were low among participants. Participants that considered gene modification of pigs acceptable justified their position using arguments that it improved animal welfare. In contrast, those that were not in favour were generally opposed to genetic modification. Unforeseen downstream consequences of using genetic modification in this manner was a major concern raised by over 80% of participants. Our findings suggest that perceived animal welfare may encourage public support of gene editing of food animals. However, potential risks of the technology need to be addressed and conveyed to the public, as many participants requested clarification of such risks as a condition for support. [ABSTRACT FROM AUTHOR]

Objectives: The aim of the present study was to present the market scenario of biotechnological drugs, especially insulin. In addition to Brazil, a study was conducted that considered the United States market, which has the largest market of biotechnological products in the world and in China, for presenting an increase in investments in the biotechnology area and is a BRICS member. Methods: A market survey of biotechnological drugs and insulin was carried out. The information that was used is provided through the IMS Health Customer Portal from 2010 to 2014, and was searched in the AliceWeb database between 2011 and 2016, and we consulted Insights magazine (published by IMS Health). Information was also obtained from the Brazilian Association of the Pharmaceutical and Pharmaceutical Industries (Abiquif) (2012–2016) and from the International Diabetes Federation (IDF), available on its websites, to identify sales of biotech drugs and, more specifically, insulin. Key findings: The deficit in the Brazilian trade balance between 2012 and 2016, related to medicines, remains high, mainly driven by the acquisition of high value‐added drugs, mainly biotechnological drugs, such as insulin. In 5 years (2010–2014), the value of the commercialization of insulin increased by an average of 100%. In 2010, the total marketing value of insulin was approximately US $16 billion, and in 2014, it was approximately US $29 billion. The three laboratories that stand out in the world, namely, Sanofi, Lilly and Novo Nordisk, are the main laboratories that market insulin in Brazil. Conclusions: The observed results make evident the import dependence for the acquisition of insulin, which can lead to a national shortage and possible cases of death and sequelae from diabetes in patients who did not receive adequate treatment, besides contributing to the trade deficit. [ABSTRACT FROM AUTHOR]

Brazilian-born artist Eduardo Kac’s (Rio de Janeiro, 1962) work has raised eyebrows especially for his ‘transgenic art’ projects, among others:Genesis, 1999;GFP Bunny, 2000;The Eight Day, 2001;Natural History of the Enigma, 2003/08. In all of these, Kac and his scientific collaborators realize genetic interventions into living organisms at the same time as they trigger audience reactions to these from playful kinds of interaction that is integrated into the works’ open and dynamic creative process. Yet whereas the ethical and political challenges Kac’s work poses have sparked lively debates within and beyond the realm of the arts – can and must art engage with the ‘creative’ potentials of biotechnology and genetics? Do these not in fact (as Vilém Flusser and others have suggested) hold the key to realizing the vanguardist dream of merging art and life? Or should the artist, from the vantage point of his own creative practice, not rather warn us against the ethical and political risks involved in genetic engineering? – much less attention has been paid to the way Kac’s art also continues and transforms a particular legacy of post-concretist, ambient and performance art in Latin America. Kac himself has referred to Brazilian artists Flávio de Carvalho, Hélio Oiticica and Lygia Clark as informing his interest in open, participative forms, which characterize both his transgenic and his earlier ‘tele-presence’ art projects. Other Latin American artists of the late twentieth and early twenty-first century have been producing intriguing engagements with living materials, multispecies habitats and organic remains, including such diverse names as Luis Fernando Benedit, Nicola Constantino, Nuno Ramos, or Teresa Margolles. In a conversation with Jens Andermann and Gabriel Giorgi at the University of Zurich’s Center of Latin American Studies on March 12, 2015, Kac addressed the way in which his work might be seen as continuing or challenging long-standing representations of the New World as a repository of ‘nature’, from colonial chronicles of discovery to contemporary discourses of biodiversity and conservation. To what extent is bio art – and the questions it raises about the Anthropocene as a threshold of radical biopolitical convergence between ‘history’ and ‘nature’ – necessarily ‘transcultural’ and planetary in its extension? [ABSTRACT FROM AUTHOR]

The wide and complex range of technologies produced and used in the contemporary societies has challenged the analysis from the different fields of social sciences. In this sense, in order to elaborate a study that aim at understanding the relationship between technological progress and the ongoing institutional changes that mark the capitalist societies, we believe it is necessary to adopt an interdisciplinary approach combining methodologies from Economics and Sociology fields. Therefore, this study proposes the development of an interdisciplinary dialogue between the economic sociology of Pierre Bourdieu and the evolutionary economics developed by authors such as Giovanni Dosi, Sidney Winter, Richard Nelson and Bhaven Sampat. In doing so, we intend to demonstrate that a theory guided by Marx's historical materialism, as it is the case of evolutionary economics, can be enriched by a materialist theory of symbolic, such as that of Pierre Bourdieu. In searching the comprehension of the complementarity between material and symbolic forces, this study addresses the conflictual process surrounding the formulation of the regulatory institutions to the biotechnology sector in Brazil over the last two decades. More precisely, through a case study, we seek to demonstrate that the convergence of discourses and interests between prestigious scientific organizations and the multinational companies that control the agrobiotechnology industry has been relevant to allow this new technological paradigm to make progress. Finally, we raise some questions concerning this alliance between business and science and the conflicts that revolve around the rapid expansion of the genetically modified crops worldwide. [ABSTRACT FROM AUTHOR]

The Brazilian human health biotechnology sector was analyzed according to its spacial and sectorial distribution of the following aspects: (i) the scientific production; (ii) innovation: sources of funding for new projects and a lack of innovative capacity regarding the discovery and development of new drugs and (iii) a disconnection between the advancement of scientific output and innovation within the private sector. The picture depicted suggests that, despite the advances being made in science and technology, it is still necessary to overcome many weaknesses to achieve an economic growth based on knowledge and innovation. [ABSTRACT FROM AUTHOR]

This article discusses the dynamics of a diameter distribution in stands of black wattle throughout its growth cycle using the Weibull probability density function. Moreover, the parameters of this distribution were related to environmental variables from meteorological data and surface soil horizon with the aim of finding a model for diameter distribution which their coefficients were related to the environmental variables. We found that the diameter distribution of the stand changes only slightly over time and that the estimators of the Weibull function are correlated with various environmental variables, with accumulated rainfall foremost among them. Thus, a model was obtained in which the estimators of the Weibull function are dependent on rainfall. Such a function can have important applications, such as in simulating growth potential in regions where historical growth data is lacking, as well as the behavior of the stand under different environmental conditions. The model can also be used to project growth in diameter, based on the rainfall affecting the forest over a certain time period. [ABSTRACT FROM AUTHOR]

The protein composition of goat milk differs between goat breeds and could present regional trends. The aim of this study was to comparatively analyze the protein composition of goat milk produced by the Alpine and Saanen breeds in northeastern Brazil and to evaluate the antibacterial activity of its protein fractions. SDS-PAGE, 2-DE electrophoresis and RP-HPLC analyses revealed the absence of αs1-casein in the milk of both breeds and no differences between the αs2-casein, β-casein, β-lactoglobulin and α-lactalbumin profiles. The amounts of soluble proteins and β-casein hydrolysis residues were higher in Saanen milk. Only the protein fraction containing the largest amounts of casein (F60–90%) inhibited bacterial growth, with MIC values between 50 and 100 mg/mL. This study describe for the first time three important points about the goat milk protein of two Brazilian goat breeders: absence of α-s1 casein in the protein profile, differences between the milk protein composition produced by goats of Alpine and Saanen breeders and antibacterial activity of unbroken proteins (casein-rich fraction) present in these milk. [ABSTRACT FROM AUTHOR]

Current knowledge of the microbial diversity and metabolic pathways involved in hydrocarbon degradation in petroleum reservoirs is still limited, mostly due to the difficulty in recovering the complex community from such an extreme environment. Metagenomics is a valuable tool to investigate the genetic and functional diversity of previously uncultured microorganisms in natural environments. Using a function-driven metagenomic approach, we investigated the metabolic abilities of microbial communities in oil reservoirs. Here, we describe novel functional metabolic pathways involved in the biodegradation of aromatic compounds in a metagenomic library obtained from an oil reservoir. Although many of the deduced proteins shared homology with known enzymes of different well-described aerobic and anaerobic catabolic pathways, the metagenomic fragments did not contain the complete clusters known to be involved in hydrocarbon degradation. Instead, the metagenomic fragments comprised genes belonging to different pathways, showing novel gene arrangements. These results reinforce the potential of the metagenomic approach for the identification and elucidation of new genes and pathways in poorly studied environments and contribute to a broader perspective on the hydrocarbon degradation processes in petroleum reservoirs. [ABSTRACT FROM AUTHOR]

Pseudokeronopsidae Borror & Wicklow, 1983 are biotechnologically important ciliate protists which produce toxic defense substances; however, their diversity is still little known in Brazil. In the present study, Tetrakeronopsis silvanetoi, a new genus and species of marine pseudokeronopsid hypotrichs is described from samples of water with bottom sediment collected from the coast of São Paulo state. Its phylogenetic affinities to the “core urostyloids” are hypothesized based on analyses of the 18S-rDNA marker, and a new subfamily, the Nothoholostichinae subfam. nov., is erected to name the monophylum composed of pseudokeronopsids in which the anterior corona is usually formed by four frontal cirri. In addition, the new combination Monocoronella longissima comb. nov. is proposed for Nothoholosticha longissima (Dragesco & Dragesco-Kernéis, 1986) Li et al., 2009. [ABSTRACT FROM AUTHOR]

Copyright of Latin American Business Review is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

: Composting operations are a rich source for prospection of biomass degradation enzymes. We have analyzed the microbiomes of two composting samples collected in a facility inside the São Paulo Zoo Park, in Brazil. All organic waste produced in the park is processed in this facility, at a rate of four tons/day. Total DNA was extracted and sequenced with Roche/454 technology, generating about 3 million reads per sample. To our knowledge this work is the first report of a composting whole-microbial community using high-throughput sequencing and analysis. The phylogenetic profiles of the two microbiomes analyzed are quite different, with a clear dominance of members of the Lactobacillus genus in one of them. We found a general agreement of the distribution of functional categories in the Zoo compost metagenomes compared with seven selected public metagenomes of biomass deconstruction environments, indicating the potential for different bacterial communities to provide alternative mechanisms for the same functional purposes. Our results indicate that biomass degradation in this composting process, including deconstruction of recalcitrant lignocellulose, is fully performed by bacterial enzymes, most likely by members of the Clostridiales and Actinomycetales orders. [ABSTRACT FROM AUTHOR]

Copyright of Organizações Rurais & Agroindustriais is the property of Organizacoes Rurais & Agroindustriais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)