1. Versatile Nickel(II) Scaffolds as Coordination‐Induced Spin‐State Switches for 19F Magnetic Resonance‐Based Detection.
- Author
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Xie, Da, Yu, Meng, Xie, Zhu‐Lin, Kadakia, Rahul T., Chung, Chris, Ohman, Lauren E., Javanmardi, Kamyab, and Que, Emily L.
- Subjects
MAGNETIC control ,NICKEL (Coin) ,IMAGING systems in chemistry ,CHEMICAL relaxation ,SPECTRAL imaging ,NUCLEAR magnetic resonance spectroscopy ,CHEMICAL shift (Nuclear magnetic resonance) - Abstract
19F magnetic resonance (MR) based detection coupled with well‐designed inorganic systems shows promise in biological investigations. Two proof‐of‐concept inorganic probes that exploit a novel mechanism for 19F MR sensing based on converting from low‐spin (S=0) to high‐spin (S=1) Ni2+ are reported. Activation of diamagnetic NiL1 and NiL2 by light or β‐galactosidase, respectively, converts them into paramagnetic NiL0, which displays a single 19F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin‐state switch is effective for sensing light or enzyme expression in live cells using 19F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for 19F MR based biosensing. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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