5 results on '"Çomak, Elif"'
Search Results
2. Predictors of poor kidney outcome in children with C3 glomerulopathy.
- Author
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Pınarbaşı, Ayşe Seda, Dursun, Ismail, Gokce, Ibrahim, Çomak, Elif, Saygılı, Seha, Bayram, Meral Torun, Donmez, Osman, Melek, Engin, Tekcan, Demet, Çiçek, Neslihan, Yılmaz, Dilek, Tabel, Yılmaz, Yıldırım, Zeynep Y., Bahat, Elif, Koyun, Mustafa, Soylu, Alper, Canpolat, Nur, Aksu, Bağdagül, Çelakıl, Mehtap Ezel, and Taşdemir, Mehmet
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TREATMENT of chronic kidney failure ,THERAPEUTIC use of monoclonal antibodies ,CHRONIC kidney failure ,DISEASE progression ,PATIENT aftercare ,HYPERTENSION ,GLOMERULAR filtration rate ,BIOPSY ,COMPLEMENT (Immunology) ,STAINS & staining (Microscopy) ,NEPHROTIC syndrome ,RETROSPECTIVE studies ,TREATMENT effectiveness ,RISK assessment ,SERUM albumin ,MEDICAL referrals ,SYMPTOMS ,DESCRIPTIVE statistics ,GLOMERULONEPHRITIS ,HEMATURIA ,HEMODIALYSIS ,PROPORTIONAL hazards models ,DISEASE remission ,DISEASE risk factors ,CHILDREN - Abstract
Background: C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G. Methods: Sixty pediatric patients with C3G from 21 referral centers in Turkey were included in this retrospective study. Patients were categorized according to CKD stage at last visit as CKD5 or non-CKD5. Demographic data, clinicopathologic findings, treatment, and outcome data were compared and possible risk factors for CKD5 progression determined using Cox proportional hazards model. Results: Mean age at diagnosis was 10.6 ± 3.0 years and follow-up time 48.3 ± 36.3 months. Almost half the patients had gross hematuria and hypertension at diagnosis. Nephritic-nephrotic syndrome was the commonest presenting feature (41.6%) and 1/5 of patients presented with nephrotic syndrome. Membranoproliferative glomerulonephritis was the leading injury pattern, while 40 patients had only C3 staining. Patients with DDD had significantly lower baseline serum albumin compared with C3GN. Eighteen patients received eculizumab. Clinical remission was achieved in 68.3%. At last follow-up, 10 patients (16.6%) developed CKD5: they had lower baseline eGFR and albumin and higher frequency of nephrotic syndrome and dialysis requirement than non-CKD5 patients. Lower serum albumin and eGFR at diagnosis were independent predictors for CKD5 development. Conclusions: Children with C3G who have impaired kidney function and hypoalbuminemia at diagnosis should be carefully monitored for risk of progression to CKD5. Graphical abstract [ABSTRACT FROM AUTHOR]
- Published
- 2021
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3. Clinical and histopathological prognostic factors affecting the renal outcomes in childhood ANCA-associated vasculitis.
- Author
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Özçelik, Gül, Sönmez, Hafize Emine, Şahin, Sezgin, Özağarı, Ayşim, Bayram, Meral Torun, Çiçek, Rümeysa Yasemin, Çakıcı, Evrim Kargın, Çomak, Elif, Barut, Kenan, Şahin, Nihal, Bakkaloğlu, Sevcan, Gökçe, İbrahim, Düzova, Ali, Bilginer, Yelda, Açarı, Ceyhun, Melek, Engin, Kılıç, Beltinge Demircioğlu, Özdel, Semanur, Adroviç, Amra, and Kasapçopur, Özgür
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KIDNEY diseases ,CHRONIC kidney failure ,AUTOANTIBODIES ,AUTOIMMUNE diseases ,BIOPSY ,CREATININE ,MEDICAL quality control ,HEALTH outcome assessment ,PEDIATRICS ,LOGISTIC regression analysis ,VASCULITIS ,SOCIOECONOMIC factors ,ANTINEUTROPHIL cytoplasmic antibodies ,CHILDREN ,DIAGNOSIS ,PROGNOSIS - Abstract
Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS).Methods: Pediatric AAV patients from 11 referral centers in Turkey had been included to the study. The demographics, clinical findings, AAV subtypes, outcomes, and FFS were evaluated retrospectively. Kidney biopsies were classified histopathologically.Results: Totally, 39 patients were enrolled in the study. Among all patients, 74.4% had renal involvement, 56.4% ear-throat-nose involvement, and 51.3% had musculoskeletal involvement. Proteinase 3 (PR3)-ANCA was positive in 48.7%, and myeloperoxidase (MPO)-ANCA was positive in 30.8%. 69.2% of patients had impaired renal function, and 28.2% had progressed to end-stage renal disease (ESRD) during the follow-up. At the time of diagnosis, FFS was ≥ 2 in 53.8%. The most common histopathologic classifications were as follows: crescentic type in 40.7% and sclerotic type in 25.9%. Gastrointestinal and renal involvement, MPO-ANCA positivity, serum creatinine levels, and impaired renal function during the follow-up were significantly higher in patients with FFS ≥ 2, compared to patients with FFS < 2. Patients with FFS ≥ 2 had more common crescentic, mixed and sclerotic histopathologic findings in biopsies. By logistic regression analysis forward method, the strongest single-risk factor among all the parameters was the initial level of creatinine in patients with ESRD, compared to the other patients (p = 0,007).Conclusions: Evaluation of the FFS, ANCA serology, and the creatinine levels may help to predict renal prognosis. [ABSTRACT FROM AUTHOR]
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- 2019
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4. CoenzymeQ10 therapy in two sisters with CoQ6 mutations with long-term follow-up.
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Koyun, Mustafa, Çomak, Elif, and Akman, Sema
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CYCLOSPORINE , *PROTEINURIA diagnosis , *THERAPEUTIC use of ubiquinones , *MYCOPHENOLIC acid , *LOSARTAN , *METHYLPREDNISOLONE , *FOCAL segmental glomerulosclerosis , *BIOPSY , *SIBLINGS , *COMBINATION drug therapy , *CONSANGUINITY , *CREATININE , *GENETIC mutation , *GLOMERULONEPHRITIS , *TERMINATION of treatment , *ALBUMINS , *DISEASE remission , *CHILDREN , *GENETICS , *DIAGNOSIS , *THERAPEUTICS - Published
- 2019
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5. Proteinuria in a male adolescent with hearing loss: Questions.
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Aksoy, Gülşah Kaya, Çomak, Elif, Akkaya, Bahar, Koyun, Mustafa, and Akman, Sema
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HEARING disorder diagnosis , *PROTEINURIA diagnosis , *ABDOMINAL pain , *AUDITORY perception testing , *BIOPSY , *BLOOD protein electrophoresis , *CONSANGUINITY , *CREATININE , *ECHOCARDIOGRAPHY , *ELECTRON microscopy , *HEMOGLOBINS , *KIDNEYS , *MITRAL valve insufficiency , *NITROGEN , *PHYSICAL diagnosis , *URINALYSIS , *ALBUMINS , *VENTRICULAR ejection fraction , *ADOLESCENCE - Abstract
The article presents a case study of a An 18-year-old boy with detection of proteinuria in the urinary analysis. Topics discussed include results of various medical tests; complications of proteinuria, abdominal pain and burning pain in feet; and the usage of microscopy, echocardiogram and kidney biopsy in the treatment.
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- 2018
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