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Background: Rapid on-site cytologic evaluation (ROSE) is not always available for fine needle aspiration (FNA) specimens. We have examined the relationships between the presence of "GOOP" (defined as gooey white material) on FNA aspirates, on-site adequacy (OSA), and diagnosis., Methods: Consecutive FNA samples obtained over the study interval were included. Samples were assessed macroscopically for the presence or absence of GOOP (GOOP+ or GOOP-). GOOP+ samples were further characterized as shiny (G+S) or cheesy (G+C). Gross descriptors were correlated with OSA and final diagnoses., Results: Of the 204 sites biopsied, 102 were malignant, 94 benign, and 8 nondiagnostic. The presence of GOOP was highly predictive for adequacy (positive predictive value 98%). While these correlations for GOOP positivity were significant, the absence of GOOP did not rule out adequacy or malignancy. The presence of GOOP was also significantly correlated with a malignant diagnosis., Conclusions: We have prospectively demonstrated that the presence of GOOP correlates strongly with adequacy. This may be of value for those for whom ROSE is not available and, when available, may help prioritize specimens for on-site review., (© 2021 S. Karger AG, Basel.)

Background: Rapid onsite evaluation (ROSE) has several potential benefits but also can prolong procedures if one must wait for a cytopathologist, and it can involve a considerable time commitment on the part of the cytopathologist. At the University of Arkansas for Medical Sciences, interventional pulmonologists have routinely reviewed cytology specimens. This study was performed to determine prospectively how accurately pulmonologists could perform ROSE and whether they could contribute to the efficiency of the process., Methods: For sequential cases, the procedural pulmonologist documented a ROSE reading before the reading by the cytopathologist. Readings were compared between the two for agreement and for accuracy. The time commitment for the cytopathologist was also recorded., Results: One hundred sixty-four sites were biopsied in 102 patients. With respect to onsite adequacy, there was a high level of concordance between pulmonology and cytopathology as evidenced by the κ score ( ± standard error) of 0.72 ± 0.15 and by disagreement in only 3 cases (2%). For the diagnostic category, there was once again a high level of concordance; there was agreement in 141 of the 164 cases (86%), and the weighted κ score was 0.89 ± 0.02. The cytopathologist's time in the endoscopy suite averaged 4.02 ± 6.9 minutes per procedure., Conclusions: Procedural pulmonologists can effectively learn enough cytology to be able to make ROSE a collaborative process and to greatly increase the efficiency of the cytopathologist., (© 2015 American Cancer Society.)

Background: The availability of portable ultrasound (US) guidance has led to usage by subspecialists outside of radiology. Several subspecialties now perform percutaneous fine-needle aspiration (PFNA) for lesions relevant to their expertise. This is a study of US-guided PFNA performed by interventional pulmonologists at a single institution., Methods: We retrospectively reviewed serial US-guided PFNAs performed at an institution with the goals of defining yield, factors relating to yield, and complication rates., Results: A total of 111 consecutive lesions were evaluated and 109 biopsied during the study period. Diagnosis was established in 81% of cases (90/109), with a total complication rate of 15% but only 1 case of a need for a higher level of care. Factors associated with increased diagnostic yield were suspicion of malignancy, increased size, and pleural adhesions (lack of pleural sliding). The presence of pleural sliding was associated with increased pneumothorax and decreased yield., Conclusions: US-guided PFNA is a valuable tool for the interventional pulmonologist. Both size and pleural sliding have an impact on diagnostic yield.