1. LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway
- Author
-
Shuai Shao, Yu Zhang, Feng Zhou, Xiaoxiang Meng, Zhenjun Yu, Guantong Li, Lina Zheng, Kun Zhang, Yuhan Li, Beichen Guo, Qi Liu, Mengxia Zhang, Xiaoxiao Du, Wei Hong, and Tao Han
- Subjects
Biophysics ,General Medicine ,Biochemistry - Abstract
Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer. Emerging evidence has indicated that long noncoding RNAs (lncRNAs) play an important role in the development of liver injury. However, the role of antisense Igf2r RNA (Airn) in acute liver injury and its underlying mechanism remain largely unclear. In this study, we show that Airn is upregulated in liver tissue and primary hepatocytes from an acute liver injury mouse model. Consistently, Airn is also overexpressed in serum samples of patients with acute-on-chronic liver failure and is negatively correlated with the Model for End-Stage Liver Disease (MELD) score. Moreover, gene knockout and rescue assays reveal that Airn alleviates CCl
- Published
- 2023