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Your search keyword '"Purdy, James P."' showing total 33 results
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33 results on '"Purdy, James P."'

4. Extremity Soft Tissue Sarcoma in Adults.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, DeLaney, Thomas F., Harmon, David C., Rosenberg, Andrew E., and Hornicek, Francis J.

Abstract

Treatment for STS requires individual tailoring of the approach because of the wide variety of clinical situations that can arise from a tumor that involves a variety of anatomic sites with a range of histologies of variable grade and size. Nevertheless, the following suggestions can serve as useful guides. Surgery is always indicated, but the use of adjuvant therapy can vary according to the anatomic site, size, and histological grade. In general, patients with superfi cial low-grade tumors that are less than 5 cm in diameter can be treated with surgical excision alone when negative margins of ≥1 cm are achieved and can expect excellent local control and survival rates approximating 90%.In patients with intermediate grade lesions, surgical excision with negative margins in combination with radiotherapy has achieved excellent local control, with overall survival rates approximating 80%. For larger, deep-seated tumors, preoperative RT appears to be more effective than postoperative radiation to prevent local tumor recurrence. Acute wound healing complications are higher with preoperative RT for lower extremity lesions, but generally irreversible late complications, including grade 3-4 fi broses, are more common in those patients receiving postoperative RT.In patients with high-grade STS greater than 5 cm, excellent local control can be achieved with surgery and radiotherapy, but at least 50% of these patients will develop metastatic disease. In this setting, the use of neoadjuvant chemotherapy may benefi t some and should be considered in the context of a clinical trial, to be followed by defi nitive surgery combined with either pre- or postoperative radiotherapy or BRT.BRT can provide excellent local control and functional results in appropriately selected patients. [ABSTRACT FROM AUTHOR]

Published
2006
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5. Testicular Cancer.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Pearse, Maria, and Morton, Gerard C.

Published
2006
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6. Carcinoma of the Vagina.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, and Cardenes, Higinia R.

Published
2006
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7. Prostate.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Michalski, Jeff M., Merrick, Gregory S., and Nilsson, Sten

Published
2006
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8. Vulva.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Vijayakumar, Srinivasan, Perez, Carlos A., and Zoberi, Imran

Published
2006
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13. Carcinoma of the Lung.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Narayan, Samir, and Vijayakumar, Srinivasan

Published
2006
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14. Carcinoma of the Esophagus.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Bradley, J. D., and Mutic, S.

Published
2006
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15. Breast Cancer.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Motwani, Sabin B., Strom, Eric A., McNeese, Marsha D., and Buchholz, Thomas A.

Published
2006
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16. Head and Neck Cancer.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Mendenhall, William M., Amdur, Robert J., and Palta, Jatinder R.

Published
2006
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17. Central Nervous System Tumors.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Stieber, Volker W., McMullen, Kevin P., Munley, Michael T., and Shaw, Edward G.

Published
2006
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22. Stereotactic Radiosurgery and Radiotherapy.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Simpson, Joseph R., Drzymala, Robert E., and Rich, Keith M.

Abstract

Stereotactic radiosurgery and radiotherapy are two valuable and increasingly applied techniques combining sophisticated brain or body imaging with stereotactic guidance and computer treatment planning for precise radiation treatment programs given either as a single large, small number of moderately large, or multiple conventional size doses with maximal sparing of adjacent normal tissues. Several devices and treatment schedules have been tested and reported on in the literature, substantiating the validity of these approaches. They have substantially increased our knowledge of tumor response and normal tissue tolerance in a very quantitative sense, and have provided useful alternative and complimentary treatments for a number of conditions. Further progress is eagerly anticipated in combining these techniques with other targeted therapies to enhance our increasingly sophisticated anti-cancer armamentarium. [ABSTRACT FROM AUTHOR]

Published
2006
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25. Three-Dimensional Treatment Planning and Conformal Therapy.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Purdy, James A., Michalski, Jeff M., Bradley, Jeffrey, Vijayakumar, Srinivasan, Perez, Carlos A., and Levitt, Seymour H.

Abstract

The use of 3D CRT treatment planning and treatment has had a major impact on the practice of radiation therapy. There are very few tumor types whose treatment has not been radically impacted by its use. For the most part this impact has been of major importance and benefit. But as with any major technical advance, the requirements for its use have had a major impact on the requirement for enhanced quality assurance from all members of the treatment team. If one carefully reads the previous sections related to the quality-assurance demands made on the entire treatment team, it is obvious that a great deal more time is required from all involved in the quest to achieve precise and increased dose to the tumor PTV, and to minimize the dose to the normal organs at risk PRV. [ABSTRACT FROM AUTHOR]

Published
2006
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30. Imaging in Radiation Therapy.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Claus, Filip, and Hricak, Hedvig

Published
2006
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31. Clinical Principles and Applications of Chemoirradiation.

Author

Brady, L. W., Heilmann, H. -P., Molls, M., Levitt, Seymour H., Purdy, James A., Perez, Carlos A., Vijayakumar, Srinivasan, Garwood, Dan P., Chinsoo Cho, L., and Choy, Hak

Abstract

The preceding discussion has been a brief overview of the varied ways in which chemotherapy and radiotherapy can be combined in treating patients with cancer. The practice of chemoirradiation is truly multidisciplinary and, as knowledge in the field expands, should play an increasing role in the control of neoplasms. As molecular biology brings us new targeted therapies, it is hoped that existing treatment regimens can be improved, in terms of both survival and ameliorating acute and late toxicity of therapy. [ABSTRACT FROM AUTHOR]

Published
2006
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