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Nanobiotechnology is a specific field of biotechnology that utilizes nanoscale methods and materials to investigate biological systems and create innovative medical technologies. This review discusses the diverse use of nanobiotechnology in health, focusing on both its superior properties and challenges. The main aims of this report are to present and elaborate on the global market share of this growing field as well as the scientific output, regarding publications and patents in the last decade. Quantitative data is derived from the Statnano database, which includes information related to the articles from the Web of Science (WoS) and approved patents from the European Patent Office and the United States Patent and Trademark Office. The final aim of this review is to provide some suggestions based on these data. Government support is the most important driving force in building up research and publications. Support for advancement in nanotechnology to fabricate products for commercial and public benefit is the top priority of developed nations. Thus, entrepreneurial training of young researchers, and collaborations between scientists, policymakers, investors, and citizens, should be encouraged. To work together globally and set international standards for the creation of consistent methods in characterizing nanoscale products with biological systems is imperative.