1. [Clinical and laboratory evaluation of the efficiency of chronic hemodialysis treatment using acidosuccinate in patients with terminal renal failure]
- Author
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A V, Smirnov, O B, Nesterova, E D, Suglobova, R V, Golubev, A N, Vasil'ev, I A, Vasil'eva, E V, Verbitskaia, N Iu, Korosteleva, E M, Kostereva, E B, Lebedeva, E N, Levykina, K G, Starosel'skiĭ, and V A, Lazeba
- Subjects
Male ,Cross-Over Studies ,Succinic Acid ,Acetates ,Middle Aged ,Treatment Outcome ,Renal Dialysis ,Dialysis Solutions ,Quality of Life ,Humans ,Kidney Failure, Chronic ,Female ,Prospective Studies ,Biomarkers ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
To evaluate the efficiency of using a succinate-containing dialysis solution (SCDS) in terminal renal failure patients treated with chronic hemodialysis (CHD).Ninety patients from two hemodialysis units took part in the crossover study and were allocated to 2 groups. For 6 months, study group patients received CHD using SCDS and control group patients had CHD with a standard bicarbonate dialysis solution after 3-month washout period followed by decussation. The time course of changes in blood biochemical parameters, 24-hour ECG monitoring data, and quality of life indicators were estimated in the patients.After using acidosuccinate during hemodialysis, there was a significant reduction in the predialysis serum level of inorganic phosphate, a calcium phosphate product, gamma-glutamyl transpeptidase, urea, and aldosterone as compared to the control group. The blood concentration of total protein was also increased. After 6-month administration of acidosuccinate, the patients showed reductions in systolic blood pressure, heart rate, and the frequency and duration of ST-segment depression episodes. There were positive changes in the quality of life of patients according to the KDQOL-SF questionnaire.The use of SCDS in patients with CHD causes positive changes in a number of laboratory parameters and improves the physical and general status, and quality of life of patients.