1. Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.
- Author
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Meneghelli M, Pasinato A, Salvadori S, Gaio P, Fantinato M, Vanzo V, De Terlizzi F, and Verlato G
- Subjects
- Absorptiometry, Photon methods, Early Medical Intervention methods, Energy Intake, Female, Humans, Infant Nutritional Physiological Phenomena, Infant, Newborn, Infant, Premature growth & development, Italy, Male, Metacarpal Bones metabolism, Metacarpal Bones pathology, Biomarkers blood, Bone Density, Bone Development physiology, Bone Diseases blood, Bone Diseases diagnosis, Bone Diseases prevention & control, Infant, Premature, Diseases blood, Infant, Premature, Diseases diagnosis, Infant, Premature, Diseases prevention & control, Parenteral Nutrition methods, Phosphates blood
- Abstract
Objective: The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status., Study Design: Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis., Result: A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT (P<0.01). Newborns with low energy intake in the first week of life (<70 kcal kg(-1) per day) and low serum phosphate level (<1.4 mmol l(-1)) at 21 days had lower mc-BTT at 36 weeks of GA (P<0.01)., Conclusion: Aggressive parenteral intakes in preterms improve growth and bone status in the short-medium term, suggesting that early nutrition could influence bone development.
- Published
- 2016
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