Olivier Deckmyn, Frédéric Charlotte, R. Myers, Philippe Mathurin, Hugo Perazzo, Mona Munteanu, An Ngo, Raluca Pais, Valentina Peta, Thierry Poynard, Rohit Loomba, Vlad Ratziu, Yen Ngo, Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), BioPredictive [Paris], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Gilead Sciences, Inc. [Foster City, CA, USA], Department of Medicine [San Diego], University of California [San Diego] (UC San Diego), University of California-University of California, University of California, The research leading to these results has received funding from the European Community’s Seventh Framework Program (FP7/2007–2013) under grant agreement HEALTHF2–2009–241762 for the project FLIP., The FLIP partners’ consortium Vlad Ratziu, Thierry Poynard: Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Sorbonne University, Paris, France, Jean-Marie Castille, Yen Ngo: Biopredictive SAS, Paris, France, Tania Langon: Alma Consulting Group SAS,Paris, France, Chris Day, Dina Tiniakos: University of Newcastle, Newcastle, UK, Debbie Lawlor: University of Bristol, Bristol, UK, Giulio Marchesini: Universita di Bologna, Bologna, Italy, Fabio Marra: University di Firenze, Firenze, Italy, Elisabetta Bugianesi: Universita degli studi di Torino, Torino, Italy, Stefano Bellentani: Universita di Modena e Reggio Emilia, Modena, Italy, Jean-Francois Dufour: Universit_ e de Berne, Berne, Switzerland, Manuel Romero Gomez: Servicio Andaluz de Salud, Spain, Thorkild Sørensen: Bispebjerg hospital, Region Hovedstaden, Bispebjerg, Dutch, Claudio Tribelli: Fondazione Italiana Fegato-Fonlus, Milano, Italy, Samuele De Minicis: Universita di Ancona, Ancona,Italy, Michael Trauner: Medizinischen Universitaet, Wien, Austria, Claudia Oliveira: University of S~ ao Paulo School of Medicine, S~ ao Paulo, Brazil. The FLIP pathology consortium Pierre Bedossa: Assistance Publique-Hopitaux de Paris, hopital Beaujon, University Paris- Diderot, Paris, France, Alastair D. Burt: School of Medicine, University of Adelaide Adelaide, Australia, Annette S.H. Gouw: Department of Pathology & Medical Biology, University Medical Center Groningen, Groningen, The Netherlands, Carolin Lackner: Institute of Pathology, Medical University of Graz, Graz, Austria, Peter Schirmacher: Institut Fur Pathologie, Universit€ atsklinikum Heidelberg, Heidelberg, Germany, Luigi Terracciano: Institute of Pathology, University Hospital, Basel, Switzerland, DinaTiniakos: Medical School, National and Kapodistrian University of Athens, Greece and Medical School, Newcastle University, Newcastle-upon-Tyne, UK, J. Brain: Medical School, Newcastle University, Newcastle-upon-Tyne, UK, Yvonne Bury: Royal Victoria Infi rmary, Hospitals Foundation Trust, Newcastle upon Tyne, UK, Daniela Cabibi: University of Palermo, Palermo, Italy, Frederic Charlotte: Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie- Salpetriere, Universite university of Torino, Ospedale Molinette, Torino, Italy, Luisa Losi: Modena University Hospital, Modena, Italy, Matteo Montani: Institute of Pathology, University of Bern, Bern, Switzerland, Marı a Jesus Pareja: Hospital Universitario de Valme, Sevilla, Spain, Dominique Wendum: Assistance Publique-Hopitaux de Paris, Hopital St Antoine Sorbonne University, Fritz Wrba: Medical University of Vienna, Vienna, Austria, Marianne Ziol: Assistance Publique-Hôpitaux de Paris, Hopital Jean Verdier, Universite Paris 13, Bobigny, France, Vlad Ratziu: Assistance Publique Hopitaux de Paris, Hopital Pitie Salpetriere, Sorbonne University, Paris,France. The FibroFrance group Thierry Poynard, Vlad Ratziu, Dominique Thabut, Joseph Moussalli, Pascal Lebray, Marika Rudler, Francoise Imbert Bismuth, Frederic Charlotte, Olivier Rosmorduc, Yvon Calmus: Anti- Fibrosis Center, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie-Salpetriere, Sorbonne University, Paris, France, Agnes Hartemann, Sophie Jacqueminet: Diabetes Center, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie-Salpetriere, Sorbonne University, Paris, France, Eric Bruckert, Philippe Giral: Lipid Center, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie-Salpetriere, Sorbonne University, Paris, France, Sylvie Naveau, Gabriel Perlemuter: Alcoholic liver Disease Center, Assistance Publique Hopitaux de Paris, Antoine Beclere Hospital, Clamart, France, Brigitte Varsat: Prevention Centers of Caisse Primaire Assurance Maladie, Paris, France, Anne Mercadier: Transfusion Unit, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie-Salpetriere, Sorbonne University, Paris, France Selonsertib group Study investigators in United States: Manal Abdelmalek, Hays Arnold, Kiran Bambha, Jaideep Behari, Stephen Caldwell, Naga Chalasani, Michael Charlton, James Cooper, Bradley Freilich, Reem Ghalib, Bilal Hameed, Kris V. Kowdley, Michelle Lai, Eric Lawitz, Rohit Loomba, Parvez Mantry, Mary Rinella, Arun Sanyal, Mitchell L. Shiffman, Paul Thuluvath, and Dawn Torres, in Canada : Saumya Jayakumar, and Magdy Elkhashab., European Project: 241762,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,FLIP(2010), Gestionnaire, Hal Sorbonne Université, Fatty liver: Inhibition of Progression - FLIP - - EC:FP7:HEALTH2010-01-01 - 2013-06-30 - 241762 - VALID, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Medicine [Univ California San Diego] (MED - UC San Diego), School of Medicine [Univ California San Diego] (UC San Diego), University of California (UC)-University of California (UC)-University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC), and University of California (UC)