1. Epidemiology of interleukin-6: the 30-year follow-up of the 1982 Pelotas (Brazil) birth cohort study.
- Author
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Santos, Francine Silva dos, Oliveira, Isabel Oliveira de, Mintem, Gicele Costa, Horta, Bernardo Lessa, and Gigante, Denise Petrucci
- Subjects
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COHORT analysis , *BODY composition , *INTERLEUKIN-6 , *EPIDEMIOLOGY , *PHYSICAL activity - Abstract
Cardiovascular diseases are the main cause of death globally. Interleukin-6 (IL-6) is a biomarker of cardiovascular risk. To investigate factors associated with IL-6 concentration in serum, from early life up to 30 years of age. In the 2012–2013 follow-up, IL-6 was measured in 2809 participants of the 1982 Pelotas Birth Cohort (1369 males). Multivariable linear regressions, stratified by sex, were performed to evaluate the associations of African ancestry, family income and maternal education at birth, monthly income and education at 30 years, smoking status, harmful alcohol intake, physical activity, and body composition with IL-6, considering a conceptual hierarchical framework. Males with low educational levels and current smokers had the highest mean IL-6. Among females, African ancestry and low monthly income were associated with the highest mean values for the outcome. Physical activity had an inverse association with IL-6 concentration among females. A direct relationship was observed between the measures of adiposity on IL-6, in both sexes. Body composition was the main predictor for the outcome evaluated in males and females. Thus, the avoidance of overweight remains an important strategy for the prevention and control of cardiovascular risk and biomarkers associated with these diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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