1. The real-life value of ST2 monitoring during heart failure decompensation: impact on long-term readmission and mortality.
- Author
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Llibre C, Zamora E, Caballero À, Lupón J, Ros A, Benito N, de Antonio M, Galán A, Domingo M, and Bayes-Genis A
- Subjects
- Aged, Female, Heart Failure epidemiology, Heart Failure physiopathology, Hospitalization, Humans, Male, Middle Aged, Patient Discharge, Prognosis, Risk Factors, Biomarkers blood, Heart Failure blood, Interleukin-1 Receptor-Like 1 Protein blood, Natriuretic Peptide, Brain blood, Peptide Fragments blood
- Abstract
Context: Prognostic value of ST2 levels and dynamics has not been investigated in acute heart failure (AHF) using prospective real-life measurements., Objective: The objective of this study is to investigate the prognostic value of ST2 in AHF., Methods: ST2 levels were determined at admission (n = 182) and discharge (n = 85). Primary endpoint was the composite of all-cause death and HF rehospitalisation at one year., Results: Discharge ST2 (HR 2.42 [95% CI 1.46-4], p = 0.001) and ΔST2 (HR 2.32 [95% CI 1.21-4.57], p = 0.01) but not admission ST2, remained independently prognostic for the primary endpoint after comprehensive multivariable adjustment. ST2 significantly improved prognosis stratification on top of clinical variables and NTproBNP., Conclusions: Routine clinical use of discharge ST2 and ST2 dynamics provide independent prognostic information.
- Published
- 2016
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