1. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I.
- Author
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Assaf HA, Abdel-Maged WM, Elsadek BE, Hassan MH, Adly MA, and Ali SA
- Subjects
- Acne Vulgaris metabolism, Adult, Blotting, Western, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Prognosis, Survivin, Young Adult, Acne Vulgaris pathology, Biomarkers metabolism, Inhibitor of Apoptosis Proteins metabolism, Insulin-Like Growth Factor I metabolism
- Abstract
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.
- Published
- 2016
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