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3 results on '"Demir, Muenevver"'

1. Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author

Benz, Fabian, Bogen, Andreas, Praktiknjo, Michael, Jansen, Christian, Meyer, Carsten, Wree, Alexander, Demir, Muenevver, Loosen, Sven, Vucur, Mihael, Schierwagen, Robert, Tacke, Frank, Trebicka, Jonel, Roderburg, Christoph, and Strnad, Pavel

Subjects
Adult, Liver Cirrhosis, Male, Patients, Science, Gastroenterology and Hepatology, Biochemistry, Severity of Illness Index, Veins, stomatognathic system, Hypertension, Portal, Medicine and Health Sciences, Humans, Integrin-Binding Sialoprotein, ddc:610, Portal Veins, Aged, Retrospective Studies, Portal Vein, Liver Diseases, Biology and Life Sciences, Ascites, Portal Hypertension, Middle Aged, Prognosis, Portal Pressure, Health Care, Cirrhosis, Cardiovascular Anatomy, Disease Progression, Medicine, Blood Vessels, Female, Anatomy, Biomarkers, Research Article
Abstract

PLOS ONE 15(4), e0231701 (2020). doi:10.1371/journal.pone.0231701, Published by PLOS, San Francisco, California, US

Published
2020

2. Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis

Author

Benz, Fabian, Bogen, Andreas, Praktiknjo, Michael, Jansen, Christian, Meyer, Carsten, Wree, Alexander, Demir, Muenevver, Loosen, Sven, Vucur, Mihael, Schierwagen, Robert, Tacke, Frank, Trebicka, Jonel, and Roderburg, Christoph

Subjects
Liver Cirrhosis, stomatognathic system, Portal Vein, Hypertension, Portal, Disease Progression, Integrin-Binding Sialoprotein, Portal Pressure, Severity of Illness Index, Biomarkers, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, 3. Good health, Retrospective Studies
Abstract

Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly asymptomatic, however, progression to a decompensated disease stage is common. The available stratification strategies are often unsuitable to identify patients with a higher risk for disease progression and a limited prognosis. SIBLINGs, soluble glycophosphoproteins, are secreted into the blood by immune-cells. While osteopontin, the most prominent member of the SIBLINGs family, has been repeatedly associated with liver cirrhosis, data on the diagnostic and/or prognostic value of bone sialoprotein (BSP) are scarce and partly inconclusive. In this study, we analyzed the diagnostic and prognostic potential of circulating BSP in comparison to other standard laboratory markers in a large cohort of patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS). Serum levels of BSP were similar in patients with different disease stages and were not indicative for prognosis. Interestingly, BSP serum levels did correlate inversely with portal pressure, as well as its surrogates such as platelet count, the portal vein cross-sectional area and correlated positively with the portal venous velocity. In summary, our data highlight that BSP might represent a previously unrecognized marker for portal hypertension in patients with liver cirrhosis.

3. FIB-4 Is a Potential Tool for Hepatocellular Carcinoma Risk Stratification in Ethnically Diverse Chronic Hepatitis B Patients When Using Specific Cutoff Values.

Author

Kuetting, Fabian, Lang, Sonja, Schramm, Christoph, Kasper, Philipp, Goeser, Tobias, Steffen, Hans-Michael, and Demir, Muenevver

Subjects
*ACADEMIC medical centers, *ANTIVIRAL agents, *BIOMARKERS, *CONFIDENCE intervals, *ALCOHOL drinking, *ETHNIC groups, *HEPATOCELLULAR carcinoma, *OUTPATIENT services in hospitals, *LONGITUDINAL method, *MEDICAL records, *TYPE 2 diabetes, *RISK assessment, *BODY mass index, *DISEASE incidence, *RETROSPECTIVE studies, *RESEARCH methodology evaluation, *DISEASE duration, *CHRONIC hepatitis B, *ACQUISITION of data methodology, *ODDS ratio, *DISEASE complications, *DISEASE risk factors
Abstract

Background: In a previous publication, a FIB-4 cutoff value of ≥ 1.25, which had been determined in an Asian population, did not allow reliable prediction of the development of hepatocellular carcinoma (HCC) in a patient collective with chronic hepatitis B (CHB) of predominantly non-Asian descent. Objectives: Here, we aimed to validate the modified FIB-4 cutoff values as a means of stratifying the HCC risk in a non-Asian cohort seen at an outpatient university hospital liver unit in Germany. Methods: We retrospectively analyzed 350 adult patients with CHB infection. We recorded demographics, laboratory parameters, results from liver imaging, serological hepatitis B markers, antiviral treatment, and histology. We separated patients into two groups based on individual FIB-4 levels. We, then, analyzed the patients' hazard ratios for HCC and adjusted it for sex, age, antiviral medication, duration of CHB infection, body mass index, alcohol consumption, and type 2 diabetes. An additional sub-analysis was performed by including only non-cirrhotic patients to determine the validity of the proposed cutoffs in that cohort. Results: The median duration of follow-up was 8.9 years with a range of 1 - 21.3 years. Our patients were 65% males. In comparison with patients that had a low FIB-4 (≥ 0.3635), those with elevated FIB-4 (≥ 0.3635) had an HCC incidence hazard ratio of 11.67 (95% confidence interval (CI): 2.73 - 49.96; P = 0.001) and an adjusted hazard ratio of 7.90 (95% CI: 1.58 - 39.39; P = 0.012). Elevated FIB-4 non-cirrhotic patients had a hazard ratio (HR) of 15.88 (95% CI: 2.04 - 123.20) for HCC incidence (P < 0.0001) and an adjusted HR of 11.99 (95% CI: 1.36 - 105.72) (P = 0.001). Conclusions: A FIB-4 value of < 0.3635 appears to be a clinical indicator for a low likelihood of HCC incidence in non-Asian patients with CHB with or without cirrhosis. Further studies in patients of diverse descent are necessary to prove its utility as a clinical tool in this setting. [ABSTRACT FROM AUTHOR]

Published
2019
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